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Pirbright study to improve the production and supply of foot-and-mouth disease vaccine

Researchers at The Pirbright Institute have secured almost $1.5 million from the Bill and Melinda Gates Foundation to fund the development of improved foot-and-mouth disease (FMD) vaccines for East Africa. The project, headed by Dr Bryan Charleston, Interim Director and CEO…

Infection route is key to testing effectiveness of swine flu vaccines

Studies assessing the effectiveness of anti-viral treatments for swine flu and those seeking to understand the behaviour of the virus, must factor in the route of infection during experiments, as this has a greater impact on results than previously thought, a new study from…

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Molecular and epidemiological features of peste des petits ruminants outbreak during endemic situation

An outbreak of peste des petits ruminants (PPR), possibly caused by the introduction of new animals in the herd, was investigated in an unvaccinated mixed herd of sheep and goats. Goats in the herd showed characteristic signs of PPR including nasal and ocular discharges…

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Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2016)

This article lists the changes to virus taxonomy approved and ratified by the International Committee on Taxonomy of Viruses (ICTV) in April 2016. Changes to virus taxonomy (the Universal Scheme of Virus Classification of the International Committee on Taxonomy of Viruses…

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Progress and knowledge gaps in Culicoides genetics, genomics and population modelling: 2003 to 2014

In the 10 years, since the last international meeting on Bluetongue virus (BTV) and related Orbiviruses in Sicily, there have been huge advances in explorations of the genetics and genomics of Culicoides, culminating in the imminent release of the rst full genome de novo…

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Working with GM vaccines: engaging the public

The UK Veterinary Vaccinology Network was among the sponsors of this year's Cheltenham Science Festival, which took place from June 7 to 12. During the festival, Adrian Hill and Andrew Pollard, of the Jenner Institute, and Bryan Charleston, of the Pirbright Institute…

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English pig farmers' knowledge and behaviour towards African swine fever suspicion and reporting

African swine fever (ASF) is a notifiable, virulent swine disease, and is a major threat to animal health and trade for many European Union (EU) countries. Early detection of the introduction of ASF virus is of paramount importance to be able to limit the potential extent of…

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Distinct immune responses and virus shedding in pigs following aerosol, intra-nasal and contact infection with pandemic swine influenza A virus, A(H1N1)09

Influenza virus infection in pigs is a major farming problem, causing considerable economic loss and posing a zoonotic threat. In addition the pig is an excellent model for understanding immunity to influenza viruses as this is a natural host pathogen system. Experimentally…

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Enhanced immunosurveillance for animal morbilliviruses using vesicular stomatitis virus (VSV) pseudotypes

The measurement of virus-specific neutralising antibodies represents the gold-standard for diagnostic serology. For animal morbilliviruses, such as peste des petits ruminants (PPRV) or rinderpest virus (RPV), live virus-based neutralisation tests require high-level…

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The conserved N-terminus of human rhinovirus capsid protein VP4 contains membrane pore-forming activity and is a target for neutralising antibodies

Human rhinovirus is the causative agent of the common cold and belongs to the non-enveloped picornavirus family. A trigger such as receptor binding or low pH initiates conformational changes in the capsid that allow the virus to attach to membranes and form a pore for the…