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World Zoonoses Day: New study highlights how Pirbright research helps protect animals and humans

An international research collaboration exploring new ways to control influenza viruses led by The Pirbright Institute has provided insights that could lead to the design of better vaccines for animals and humans. Pirbright scientists are highlighting this research today -…

CMO report encourages use of genome sequencing across healthcare systems

Today the Government’s Chief Medical Officer, Professor Dame Sally Davies, published her annual report “ Generation Genome” - with a call to embrace genome sequencing and mainstream it into modern health care. The report highlights the many areas to which genetic sequencing…

News feature: the emergence of lumpy skin disease in Europe

Lumpy skin disease (LSD) is an important disease of cattle which was first seen in southern Africa in the 1920s. It is now found throughout Africa, and more recently has spread into the Middle East. In 2015 the disease entered Europe for the first time, resulting in the…

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Identification of cross-reacting T-cell epitopes in structural and non-structural proteins of swine and pandemic H1N1 influenza A virus strains in pigs

Heterologous protection against swine influenza viruses (SwIVs) of different lineages is an important concern for the pig industry. Cross-protection between 'avian-like' H1N1 and 2009 pandemic H1N1 lineages has been observed previously, indicating the involvement of cross…

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Comparative phenotypic and functional analyses of the effects of autologous plasma and recombinant human macrophage-colony stimulating factor (M-CSF) on porcine monocyte to macrophage differentiation

Porcine monocyte-derived macrophages (moM?) have been employed as a model cell in numerous studies of the porcine immune system. However, the lack of a standardized method for moM? differentiation hampers the comparison of results coming from the use of different laboratory…

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Dual recognition element lateral flow assay toward multiplex strain specific influenza virus detection

Different influenza virus strains have caused a number of recent outbreaks killing scores of people and causing significant losses in animal farming. Simple, rapid, sensitive, and specific detection of particular strains, such as a pandemic strain versus a previous seasonal…

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Chicken IFN Kappa: a novel cytokine with antiviral activities

Interferons (IFNs) are essential components of the host innate immune system and define first-line of defence against pathogens. In mammals, several type I IFNs are identified, however, only limited data is available on the repertoire of IFNs in avian species. Here we report…

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Variable BCG efficacy in rhesus populations: Pulmonary BCG provides protection where standard intra-dermal vaccination fails

M.bovis BCG vaccination against tuberculosis (TB) notoriously displays variable protective efficacy in different human populations. In non-human primate studies using rhesus macaques, despite efforts to standardise the model, we have also observed variable efficacy of BCG…

New study shows early detection of foot-and-mouth disease could help limit culling

Pre-clinical diagnosis could be key to helping control the transmission of foot-and-mouth disease virus (FMDV) in the event of an outbreak, a new study from scientists at The Pirbright Institute and Wageningen Bioveterinary Research has concluded. Foot-and-mouth disease (FMD…

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Control of the induction of type I interferon by peste des petits ruminants virus

Peste des petits ruminants virus (PPRV) is a morbillivirus that produces clinical disease in goats and sheep. We have studied the induction of interferon-β (IFN-β) following infection of cultured cells with wild-type and vaccine strains of PPRV, and the effects of such…