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Targeted editing of the pp38 gene in Marek's disease virus-transformed cell lines using CRISPR/Cas9 system

Marek's disease virus (MDV), a lymphotropic alpha-herpesvirus associated with T-cell lymphomas in chickens, is an excellent model for herpesvirus biology and virus-induced oncogenesis. Marek's disease (MD) is also one of the cancers against which a vaccine was first used. In…

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Attenuation of infectious bronchitis virus in eggs results in different patterns of genomic variation across multiple replicates

The gammacoronavirus infectious bronchitis virus (IBV) causes an acute, highly contagious respiratory disease of poultry. Live attenuated vaccines are traditionally generated by serial passage of a virulent strain in embryonated chicken eggs, however the molecular mechanism…

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Characterisation and abundance of Culicoides biting midges present on dairy farms

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Detection of a novel reassortant epizootic hemorrhagic disease virus serotype 6 in cattle in Trinidad, West Indies, containing nine RNA segments derived from exotic EHDV strains with an Australian origin

Epizootic hemorrhagic disease virus (EHDV) is a Culicoides-transmitted orbivirus that infects domestic and wild ruminants in many parts of the world. Of the eight proposed serotypes, only EHDV-1, 2 and 6 have been reported to be present in the Americas. Following the…

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Evaluation of molecularly imprinted polymers as synthetic virus neutralizing antibody mimics

Rapid development of antibody-based therapeutics are crucial to the agenda of innovative manufacturing of macromolecular therapies to combat emergent diseases. Although highly specific, antibody therapies are costly to produce. Molecularly imprinted polymers (MIPs)…

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Long-term shifts in the seasonal abundance of adult Culicoides biting midges and their impact on potential arbovirus outbreaks

Surveillance of adult Culicoides biting midge flight activity is used as an applied ecological method to guide the management of arbovirus incursions on livestock production in Europe and Australia. To date the impact of changes in the phenology of adult vector activity on…

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Mass die-off of saiga antelopes, Kazakhstan, 2015

In 2015, a mass die-off of approximately 200,000 saiga antelopes in central Kazakhstan was caused by hemorrhagic septicemia attributable to the bacterium Pasteurella multocida serotype B. Previous analyses have indicated that environmental triggers associated with weather…

World-class facilities for virus research

Multi-million pound laboratory completed at Institute for Animal Health "Now if you want to come and film these areas you'll have to take your camera out via the quarantine facility... which means it may be fumigated and lost forever." Dr Michael Johnson, Head of Estates at…

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Meeting report: Global Alliance for Research on Avian Diseases 2018, International Conference, January 17 to 19, 2018, Hanoi, Vietnam

Poultry production is one of the fastest growing sectors of the livestock industry, growing at a rate of around 5% per year (2015-16) to meet the global demands and food security, as shown by European Union Open Data Portal. One of the major challenges for the sustainable…

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Pathogenic Mannheimia haemolytica invades differentiated bovine airway epithelial cells

The Gram-negative bacterium Mannheimia haemolytica is the primary bacterial species associated with bovine respiratory disease (BRD) which is responsible for significant economic losses to the livestock industries worldwide. Healthy cattle are frequently colonised by…