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Sheep breed and shearing influences attraction and blood-feeding behaviour of Culicoides (Diptera: Ceratopogonidae) on a UK farm

Culicoides biting midges (Diptera: Ceratopogonidae) are responsible for the biological transmission of arboviruses of international importance between ruminant livestock. These arboviruses include bluetongue virus (BTV) and Schmallenberg virus (SBV), which have emerged in…

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Sheep breed and shearing influences attraction and blood-feeding behaviour of Culicoides (Diptera: Ceratopogonidae) on a UK farm

Culicoides biting midges (Diptera: Ceratopogonidae) are responsible for the biological transmission of arboviruses of international importance between ruminant livestock. These arboviruses include bluetongue virus (BTV) and Schmallenberg virus (SBV), which have emerged in…

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Removal of the N-glycosylation sequon at position N116 located in P27 of the respiratory syncytial virus fusion protein elicits enhanced antibody responses after DNA immunization

Prevention of severe lower respiratory tract infections in infants caused by the human respiratory syncytial virus (hRSV) remains a major public health priority. Currently, the major focus of vaccine development relies on the RSV fusion (F) protein since it is the main…

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The genome of the biting midge Culicoides sonorensis and gene expression analyses of vector competence for bluetongue virus

The new genomic technologies have provided novel insights into the genetics of interactions between vectors, viruses and hosts, which are leading to advances in the control of arboviruses of medical importance. However, the development of tools and resources available for…

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Generation and characterisation of recombinant FMDV antibodies: Applications for advancing diagnostic and laboratory assays

Foot-and-mouth disease (FMD) affects economically important livestock and is one of the most contagious viral diseases. The most commonly used FMD diagnostic assay is a sandwich ELISA. However, the main disadvantage of this ELISA is that it requires anti-FMD virus (FMDV)…

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Generation and characterisation of recombinant FMDV antibodies: Applications for advancing diagnostic and laboratory assays

Foot-and-mouth disease (FMD) affects economically important livestock and is one of the most contagious viral diseases. The most commonly used FMD diagnostic assay is a sandwich ELISA. However, the main disadvantage of this ELISA is that it requires anti-FMD virus (FMDV)…

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Tackling human and animal health threats through innovative vaccinology in Africa

Africa bears the brunt of many of the world's most devastating human and animal infectious diseases, a good number of which have no licensed or effective vaccines available. The continent's potential to generate novel interventions against these global health threats is…

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Reticuloendotheliosis virus and avian leukosis virus subgroup J synergistically increase the accumulation of exosomal miRNAs

Co-infection with avian leukosis virus subgroup J and reticuloendotheliosis virus induces synergistic pathogenic effects and increases mortality. However, the role of exosomal miRNAs in the molecular mechanism of the synergistic infection of the two viruses remains unknown…

Meetings on avian viruses and immunology

Next week two consecutive meetings will focus on research into avian diseases that affect both food security and human health. The Focused Meeting on Molecular Biology and Pathogenesis of Avian Viruses and XV Avian Immunology Research Group (AIRG) meeting will take place on…

Globe and vaccine vials

Further development of low cost foot-and-mouth disease vaccine funded £2.1million

The Pirbright Institute has a received a £2.1 million grant from The Bill and Melinda Gates Foundation to conduct research on a novel foot-and-mouth disease (FMD) vaccine. Scientists will investigate the cattle antibody responses triggered by the vaccine which will help them…