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Global quest for vaccine to cut methane in cattle

Scientists are to search for a proof-of-concept vaccine that can cut methane emissions in cattle. Supported by $9.4 million from the Bezos Earth Fund and led by researchers at The Pirbright Institute and the Royal Veterinary College (RVC), an international consortium will…

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Empirical and model-based evidence for a negligible role of cattle in peste des petits ruminants virus transmission and eradication

Peste des petits ruminants virus (PPRV) is a multi-host pathogen with sheep and goats as main hosts. To investigate the role of cattle in the epidemiology of PPR, we simulated conditions similar to East African zero-grazing husbandry practices in a series of trials with…

Pirbright expertise informs pandemic readiness report

Expert insight from leading scientists at The Pirbright Institute has informed a World Health Organisation (WHO) report calling on researchers and governments to accelerate global research in readiness for the next pandemic. WHO and the Coalition for Epidemic Preparedness…

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The dual role of a highly structured RNA (the S fragment) in the replication of foot-and-mouth disease virus

Secondary and tertiary RNA structures play key roles in genome replication of single-stranded positive sense RNA viruses. Complex, functional structures are particularly abundant in the untranslated regions of picornaviruses, where they are involved in initiation of…

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Arthropod-Borne Viruses of Human and Animal Importance: Overwintering in Temperate Regions of Europe during an Era of Climate Change

The past three decades have seen an increasing number of emerging arthropod-borne viruses in temperate regions This process is ongoing, driven by human activities such as inter-continental travel, combined with the parallel emergence of invasive arthropods and an underlying…

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Specific and Sensitive Visual Proviral DNA Detection of Major Pathogenic Avian Leukosis Virus Subgroups Using CRISPR-Associated Nuclease Cas13a

Avian leukosis viruses (ALVs) include a group of avian retroviruses primarily associated with neoplastic diseases in poultry, commonly referred to as avian leukosis. Belonging to different subgroups based on their envelope properties, ALV subgroups A, B, and J (ALV-A, ALV-B…

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One-pot Golden Gate Assembly of an avian infectious bronchitis virus reverse genetics system

Avian infectious bronchitis is an acute respiratory disease of poultry of particular concern for global food security. Investigation of infectious bronchitis virus (IBV), the causative agent of avian infectious bronchitis, via reverse genetics enables deeper understanding of…

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Single-cell analysis reveals lasting immunological consequences of influenza infection and respiratory immunization in the pig lung

The pig is a natural host for influenza viruses and integrally involved in virus evolution through interspecies transmissions between humans and swine. Swine have many physiological, anatomical, and immunological similarities to humans, and are an excellent model for human…