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Genetic diversity and population structure of Culex modestus across Europe: does recent appearance in the United Kingdom reveal a tendency for geographical spread?

In mainland Europe, the mosquito species Culex modestus Ficalbi (1890) is a bridge vector for West Nile virus (WNV) from its natural bird-mosquito cycle to mammals. The present study assessed the genetic diversity of Cx. modestus, as well as related Culex species, using the…

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African swine fever epidemiology and control

African swine fever is a devastating disease that can result in death in almost all infected pigs. The continuing spread of African swine fever from Africa to Europe and recently to the high-pig production countries of China and others in Southeast Asia threatens global pork…

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Application of HDR-CRISPR/Cas9 and erythrocyte binding for rapid generation of recombinant turkey herpesvirus-vectored avian influenza virus vaccines

Avian influenza viruses (AIVs) are highly contagious and have caused huge economical loss to the poultry industry. AIV vaccines remain one of the most effective methods of controlling this disease. Turkey herpesvirus (HVT) is a commonly used live attenuated vaccine against…

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Glutaminolysis and glycolysis are essential for optimal replication of Marek's disease virus

Viruses may hijack glycolysis, glutaminolysis or fatty acid β-oxidation of host cells to provide energy and macromolecules required for efficient viral replication. Marek's disease virus (MDV) causes a deadly lymphoproliferative disease in chickens and modulates metabolism…

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Morbilliviruses: Entry, Exit and Everything In-Between

Morbilliviruses are important pathogens, to the point that they have shaped the history of human and animal health.

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CRISPR/Cas9 gene editing in the West Nile Virus vector, Culex quinquefasciatus Say

Culex quinquefasciatus Say is an opportunistic blood feeder with a wide geographic distribution which is also a major vector for a range of diseases of both animals and humans. CRISPR/Cas technologies have been applied to a wide variety of organisms for both applied and…

Marek's disease virus infected chicken cells

Pirbright scientists demonstrate Marek’s disease virus causes ‘addiction’ in cells

Researchers from The Pirbright Institute have shown that glutamine, a protein building block, is essential for the replication of Marek’s disease virus in chickens. Their study revealed that cells infected with the virus were unable to survive glutamine deprivation, a…

Group photo of Gnatwork workshop attendees

Pirbright scientists lead Gnatwork training for international scientists on key vector research skills

Between 4-8 November 2019, the Gnatwork trained a group of 28 international early career researchers at Universidade Federal De Minas Gerais (UFMG), Brazil, to develop the essential skills needed to work with three neglected species of insects that transmit diseases; midges…

Pirbright enters bioimaging collaboration with Diamond Light Source

A new five-year collaboration has been agreed between The Pirbright Institute and Diamond Light Source that will help our scientists to study viral diseases in greater detail. The new relationship will bring together two internationally renowned institutions that form an…

Antibodies trapped in floating bubbles

Bill & Melinda Gates Foundation funds development of Pirbright’s Livestock Antibody Hub supporting animal and human health

Researchers from The Pirbright Institute have been awarded US $5.5 million by the Bill & Melinda Gates Foundation to establish a Livestock Antibody Hub aimed at improving animal and human health globally. The ambitious programme of work will see extensive collaboration…