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Nomenclature report for killer-cell immunoglobulin-like receptors (KIR) in macaque species: new genes/alleles, renaming recombinant entities and IPD-NHKIR updates

The Killer-cell Immunoglobulin-like Receptors (KIR) are encoded by a diverse group of genes, which are characterized by allelic polymorphism, gene duplications, and recombinations, which may generate recombinant entities. The number of reported macaque KIR sequences is…

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Post-vaccination herd immunity against peste des petits ruminants and inter-vaccination population turnover in small ruminant flocks in northwest Ethiopia

Vaccination is the main tool for control of peste des petits ruminants (PPR) because of the availability of effective and safe vaccines that provide long lasting protection. However vaccination campaigns may not always provide sufficient herd immunity needed to prevent…

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Differential expression of immune-related genes in the bursa of Fabricius of two inbred chicken lines following infection with very virulent infectious bursal disease virus

Among different inbred chickens' lines, we previously showed that lines P and N of Institute for Animal Health, Compton, UK are the most susceptible and the least affected lines, respectively, following infection with very virulent infectious bursal disease virus (vvIBDV)…

Pirbright study uncovers replication sites of emerging pig disease

A recent study carried out at The Pirbright Institute has uncovered the sites within the cell where porcine deltacoronavirus (PDCoV) makes new copies of itself during replication. Using electron microscopy, Pirbright scientists demonstrated that the virus creates replication…

Pirbright study uncovers replication sites of emerging pig disease

A recent study carried out at The Pirbright Institute has uncovered the sites within the cell where porcine deltacoronavirus (PDCoV) makes new copies of itself during replication. Using electron microscopy, Pirbright scientists demonstrated that the virus creates replication…

Pirbright student wins award to study the role of insects in lumpy skin disease infection

First year PhD student Charlotte Cook was recently thrilled to learn that she is being given an In Vivo Skills Award from the Biotechnology and Biological Sciences Research Council (BBSRC), part of UK Research and Innovation. Only three such awards are offered by the BBSRC…

pig lying in hay pirbright

Pigs can be used to test human flu vaccines say Pirbright scientists

A new study from researchers at The Pirbright Institute suggests that pigs may be a good model for evaluating the effectiveness of vaccines designed to protect against seasonal human flu. In a paper published in the journal Frontiers in Immunology the study, led by Dr Elma…

KMO knock-out mosquitoes. One the left with black eyes, on the right with white eyes.

Pirbright scientists create white eyed mosquitoes to progress genetic population control methods

Researchers at The Pirbright Institute have used the CRISPR/Cas9 gene editing tool to knock out a gene in Culex quinquefasciatus Say, an understudied species of mosquito that spreads a variety of bird, animal and human diseases, including West Nile virus. The study provides…

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FMD vaccine matching: inter laboratory study for improved understanding of r1 values

Foot-and-mouth disease virus (FMDV) is a highly variable RNA virus existing as seven different serotypes. The antigenic variability between and within serotypes can limit the cross-reactivity and therefore the in vivo cross-protection of vaccines. Selection of appropriate…

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An Illumina approach to MHC typing of Atlantic salmon

The IPD-MHC Database represents the official repository for non-human major histocompatibility complex (MHC) sequences, overseen and supported by the Comparative MHC Nomenclature Committee, providing access to curated MHC data and associated analysis tools. IPD-MHC gathers…