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Nurturing emerging leaders in science

Two talented Pirbright researchers have been awarded with Strategic Career Development Awards (SCDAs) to advance their research and career trajectories. Dr Rory Fortes de Brito, a Senior Postdoctoral researcher in the Porcine Reproductive and Respiratory Syndrome (PRRS)…

Cattle and goats in Tanzania

Pirbright joins UKRI-backed network to tackle livestock diseases

The Pirbright Institute is joining a new network which aims to help detect, predict and prevent viral diseases that threaten animals. Funded by UK Research and Innovation (UKRI) the One Health Computational Network (OHCN) is an interdisciplinary project strengthening UKRI’s…

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Corrigendum to “Evaluation of commercial quadrivalent foot-and-mouth disease vaccines against east African virus strains reveals limited immunogenicity and duration of protection” [Vaccine 42 (1–12) (2024) 126325]

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No evidence that mutations in SARS-CoV-2 variants of concern derive from homologous fragments in gut microbiota

Understanding the origin and evolution of mutations in SARS-CoV-2 variants of concern (VOCs) is a critical area of research. B. Cao, X. Wang, W. Yin, Z. Gao, and B. Xia (mBio 15:e03187-23, 2024, https://doi.org/10.1128/mbio.03187-23) proposed that these mutations originated…

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Development of bovine IgG3-specific assays using a novel recombinant single-domain binding reagent

Cattle express three subclasses of IgG antibody - IgG1, IgG2 and IgG3. Unlike IgG1 and IgG2, IgG3 was described relatively recently and the role of this subclass in immunity is unknown. Using recombinant bovine IgG1, IgG2 and IgG3 monoclonal antibodies (mAbs), we…

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Cell entry mechanisms of African swine fever virus

African swine fever virus (ASFV) is a highly complex virus that poses a significant threat to the global swine industry. However, little is known about the mechanisms of ASFV cell entry because ASFV has a multilayered structure and a genome encoding over 150 proteins. This…

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Undiagnosed West Nile virus lineage 2d infection in a febrile patient from South-west Uganda, 2018

We report the retrospective identification and subsequent recovery of a near-complete West Nile Virus lineage 2 genomes from a hospitalized patient with acute febrile illness in Uganda, using a combination of degenerate primer polymerase chain reaction screening and a novel…

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Using the basic reproduction ratio to quantify transmission and identify data gaps for epizootic haemorrhagic disease virus

Epizootic haemorrhagic disease virus (EHDV) is an arbovirus transmitted by Culicoides biting midges that has recently emerged in Europe. Here, the basic reproduction ratio (R0) was used to quantify the transmission of EHDV and its dependence on temperature for cattle and…

Pig sniffing at apple

Outbred pigs can serve as model for human therapeutics

Laboratory-made monoclonal antibodies are used to treat conditions including cancer, autoimmune and infectious diseases. Commercial outbred pigs can be used as models to test how quickly therapeutic monoclonal antibodies (mAbs) disappear from the human body after injection…

Emerging threat: Study reveals gaps in knowledge about EHDV transmission in Europe

A new study highlights significant gaps in our understanding of the transmission dynamics of epizootic haemorrhagic disease virus (EHDV) which primarily infects cattle and deer. EHDV was detected in Europe for the first time in 2022, with outbreaks reported in Italy and…