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The characterisation of chIFITMs in avian coronavirus infection in vivo, ex vivo and in vitro

The coronaviruses are a large family of enveloped RNA viruses that commonly cause gastrointestinal or respiratory illnesses in the infected host. Avian coronavirus infectious bronchitis virus (IBV) is a highly contagious respiratory pathogen of chickens that can affect the…

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The characterisation of chIFITMs in avian coronavirus infection in vivo, ex vivo and in vitro

The coronaviruses are a large family of enveloped RNA viruses that commonly cause gastrointestinal or respiratory illnesses in the infected host. Avian coronavirus infectious bronchitis virus (IBV) is a highly contagious respiratory pathogen of chickens that can affect the…

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Avian leukosis virus subgroup J induces B cell anergy mediated by Lyn inhibited BCR signal transduction

Immune tolerance induced by avian leukosis virus subgroup J (ALV-J) is a prerequisite for tumorigenesis. Although we had reported that B cell anergy induced by ALV-J was the main reason for immune tolerance, the molecular mechanism still remains unclear. Here, we found SU…

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Towards a sampling rationale for African swine fever virus detection in pork products

African swine fever (ASF) is a highly lethal disease of pigs caused by the ASF virus (ASFV), which presents a serious threat to global food security. The movement of contaminated pork products has previously been postulated as contributing to the introduction of ASF into new…

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Towards a sampling rationale for African swine fever virus detection in pork products

African swine fever (ASF) is a highly lethal disease of pigs caused by the ASF virus (ASFV), which presents a serious threat to global food security. The movement of contaminated pork products has previously been postulated as contributing to the introduction of ASF into new…

Influenza filamentous and globular (shown in brown)

Bird flu mutations reduce antiviral drug effectiveness, Pirbright study reveals

Four mutations in bird flu viruses allow them to escape human antiviral drugs without compromising their fitness, studies at The Pirbright Institute have revealed. If flu strains with these mutations make the jump from birds to humans, available options for prevention and…

Black cow in barn

Contaminated surroundings risk foot-and-mouth disease spread

Understanding how long a disease can be transmitted for is a cornerstone in preventing and controlling outbreaks, particularly when there is more than one route of infection. Scientists at The Pirbright Institute and Wageningen Bioveterinary Research have demonstrated that…

genetically engineered mosquito shown with red, blue and green fluorescence markers

Pirbright paves way for disease resistant mosquitoes

A team of researchers at The Pirbright Institute have used genetic engineering to disable the chikungunya virus genome in mosquito cells. With further development, the technology could help researchers to engineer disease resistant mosquitoes, which would make them unable to…

Beaudette infection in primary chicken kidney cell cultures. They have been labelled anti-E (red) and anti-IBV (green) and the nuclei are labelled blue with DAPI.

Increasing infectious bronchitis virus vaccine heat resilience could improve performance, Pirbright scientists reveal

Two recent studies from The Pirbright Institute and the University of Edinburgh’s Roslin Institute show that two vaccines against specific strains of infectious bronchitis virus (IBV) do not offer complete protection against a third strain, and that this may be partly down…

Beaudette infection in primary chicken kidney cell cultures. They have been labelled anti-E (red) and anti-IBV (green) and the nuclei are labelled blue with DAPI.

Increasing infectious bronchitis virus vaccine heat resilience could improve performance, Pirbright scientists reveal

Two recent studies from The Pirbright Institute and the University of Edinburgh’s Roslin Institute show that two vaccines against specific strains of infectious bronchitis virus (IBV) do not offer complete protection against a third strain, and that this may be partly down…