Postdoctoral Scientist

The Pirbright institute delivers world-leading research to understand, predict, detect and respond to viral disease outbreaks. We study viruses of livestock that are endemic and exotic to the UK, including zoonotic viruses, by using the most advanced tools and technologies to understand host-pathogen interactions in animals and arthropod vectors. Our major strength in understanding the immune systems of livestock provides a platform to control current diseases and respond to emerging threats. This important research would not be possible without the proportionate use of animals, which are integral to the development of new disease control measures such as vaccines and diagnostics. We have an establishment-wide commitment to the 3rs (replacement, reduction and refinement), high standards of animal welfare, a culture of care and openness.

Our institute is made up of a dynamic and vibrant community of staff covering a diverse set of chosen fields, backgrounds and experience. We all play a crucial role in furthering the institute’s aspirations, advancing the frontiers of science and knowledge through our excellent scientific research, knowledge sharing and contribution; with a real focus in improving the world in which we live. Our outlook is always balanced by our strong sense of purpose, values and behaviours and an unwavering commitment to a ‘one institute’ approach.

Organisation position and purpose

This position presents an exciting, unique opportunity to join a pioneering One Health research initiative at the forefront of infectious disease science.

You will be part of a cutting-edge effort to interrupt the transmission of respiratory viruses such as influenza and coronaviruses - persistent global public health challenges despite the availability of current vaccines and antivirals.

The project harnesses the pig as a powerful, large animal model, offering a uniquely relevant system due to its close physiological, anatomical, immunological, and genetic parallels to humans. As natural hosts for influenza viruses similar to those infecting humans, pigs provide an unparalleled platform for high-impact translational research. Their lung structure and immune responses offer a rare and valuable model for understanding and combating viral diseases.

As the postholder, you will lead investigations into the potential of mRNA-encoded antibodies, interferons, and other innate immune stimulators delivered to the respiratory tract to block infection and transmission. Your research will explore their ability to reduce viral shedding, minimise lung damage, and lessen disease severity. A core aspect of the role involves comparing innovative delivery strategies to identify those offering the most effective in vivo expression and protection.

Additionally, you will contribute to the generation of porcine influenza-specific monoclonal antibodies through infection or immunisation, followed by detailed characterisation of their specificity, functionality, and repertoire based on the route of administration.

To achieve these goals, you will employ a broad and advanced range of immunological and virological methods, including ELISA, microneutralisation assays, virus propagation, plaque assays, molecular cloning, antibody repertoire profiling, and bioinformatics. These techniques are vital for evaluating both immune responses and the therapeutic potential of novel interventions.

This is a rare chance to play a central role in translational, interdisciplinary research with direct implications for vaccine and therapeutic innovation in both human and veterinary health. The successful candidate will report to the Head of the Mucosal Immunology Group and engage closely with leading collaborators across the BMGF network.

Main duties and responsibilities:

Responsible for conducting research into transmission of and immunity to influenza viruses

• Analyse B and T cell responses following influenza infection
• Characterise and isolate antigen-specific B cells using flow cytometry
• Perform antibody repertoire analysis
• Clone and express influenza-specific monoclonal antibodies using recombinant techniques
• Determine the antigen specificity and functional activity of monoclonal antibodies, including neutralisation, binding assays, ELISA, haemagglutination inhibition (HAI), antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), and antibody-dependent cellular phagocytosis (ADCP)
• Prepare virus challenge material and quantify viral loads in tissue samples
• Assist in the execution of influenza animal challenge studies

Responsible for working as part of a research team, which will include

• Present research findings at internal meetings and external scientific conferences
• Prepare and contribute to the writing of scientific manuscripts for publication
• Support the supervision and mentoring of undergraduate, MSc, and PhD students, as well as junior research staff
• Adapt existing methodologies and develop new scientific techniques and experimental protocols as required
• Contribute to the preparation and writing of research grant proposals to support ongoing and future projects
• Assist with laboratory management, including ordering supplies, maintaining equipment, and managing sample inventories
• Maintain accurate documentation related to health, safety, and biosecurity protocols to ensure a safe and compliant working environment
• Participate in outreach and public engagement activities as part of the group’s commitment to broader impact

Essential/Desirable requirements

Essential

• A PhD or equivalent qualification in a relevant biosciences discipline.
• Demonstrated excellent oral and written communication skills, including the ability to engage effectively with funding bodies, peer-review panels, and government agencies.
• Experience with influenza virology techniques, such as virus propagation and quantification, microneutralisation assays, and haemagglutination inhibition assays.
• Proficiency in immunology techniques, including flow cytometry, analysis of cellular and humoral immune responses, ELISPOT, proliferation assays, ELISA, ADCC, and ADCP.
• Ability to effectively prioritise tasks and manage time under pressure.
• Willingness to work outside regular working hours when required.

Desirable

• Previous experience working in a laboratory setting.
• Familiarity with biological containment protocols and working in biosecure environments.
• Experience handling large animals.
• Basic computer skills, including proficiency with Microsoft Office, data presentation, and statistical analysis.
• Evidence of experience and a clear vision for conducting scientific research within a multidisciplinary team.

Due to the nature of the work carried out by Pirbright, all successful applicants will be required to go through a comprehensive screening process including reference and qualification checks, financial and security clearances.

What we offer

• Generous Group Personal Pension Scheme and life cover (subject to age and earnings)
• 25 days annual leave per annum, pro rata, plus 10.5 public and privilege days
• Buy and sell annual leave
• Option to carry over up to two weeks annual leave
• Pirbright gym with subsidised membership
• Pirbright social club
• Pirbright Lifestyle Hub (employee discount site)
• Cycle to work
• Subsidised staff restaurant
• Childcare allowance
• Free onsite parking
• Electric Car charging facilities

Due to the high volume of applications, we receive, if you have not heard from us within one month from closing date of the vacancy, then please contact us on jobs@pirbright.ac.uk for an update.