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Comprehensive intrinsic disorder analysis of 6108 viral proteomes: from the extent of intrinsic disorder penetrance to functional annotation of disordered viral proteins

Much of our understanding of proteins and proteomes comes from the traditional protein structure-function paradigm. However, in the last 2 decades, both computational and experimental studies have provided evidence that a large fraction of functional proteomes across…

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Heterogeneous populations from in vitro cultures of antigen presenting cells in pigs

Dendritic cells (DCs) are the most potent antigen presenting cells (APCs). Because of the difficulty in obtaining these cells directly from tissues, different sources of DCs are frequently used for in vitro experimentation and many of their biological and functional…

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Single-shot vaccines against bovine respiratory syncytial virus (BRSV): comparative evaluation of long-term protection after immunization in the presence of BRSV-specific maternal antibodies

The induction of long-lasting clinical and virological protection is needed for a successful vaccination program against the bovine respiratory syncytial virus (BRSV). In this study, calves with BRSV-specific maternally derived antibodies were vaccinated once, either with (i…

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Isolation of porcine reproductive and respiratory syndrome virus GP5-specific, neutralizing monoclonal antibodies from hyperimmune sows

Porcine reproductive and respiratory syndrome (PRRS) is a devastating disease which impacts the pig industry worldwide. The disease is caused by PRRS viruses (PRRSV-1 and -2) which leads to abortions and other forms of reproductive failure in sows and severe respiratory…

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Pathogenesis of non-epithelial foot-and-mouth disease in neonatal animals

Foot-and-mouth disease virus (FMDV), which causes a highly contagious viral disease of cloven-hoofed animals, is notable for epithelial cell tropism, resulting in the appearance of vesicles on the feet and in and around the mouth in infected animals, while FMDV infection in…

HEPA Housing at the Pirbright Institute

HEPA Filtration - validation, testing and changing: eLearning

Learn about HEPA filters and how to test and validate.

The Pirbright Institute Flag raised on a flagpole, billowing in blue sky

New Trustees join The Pirbright Institute Trustee Board

As a registered charity, The Pirbright Institute is governed by a Board of non-executive Trustee Directors. The Institute has appointed four new Trustees for 2021: Rona Chester, Emma Griffin, Alison Hardy, and Dr Paul Logan. Pirbright also bids a fond farewell to Sir Bertie…

Cows in a field at Pirbright Compton site

New tools to define previously overlooked immune cells in cattle open avenues for treating disease

In a collaborative study, with the University of Oxford, The University of Melbourne/Doherty Institute, the University of Edinburgh’s Roslin Institute, Animal and Plant Health Agency, Utrecht University and The University of Queensland, scientists at The Pirbright Institute…

Collage of different job roles at the Institute

Science Spotlight: Supporting world-class research

Investigating viral diseases of animals requires experts from many fields. Scientists work to understand how viruses cause infection and how diseases can be controlled using vaccines and surveillance. However, there are many other professions involved in generating The…

A pig in straw in the high containment animal facilities at The Pirbright Institute

Pirbright generates first pig flu antibodies that could improve human treatments and guide flu vaccine selection

The Pirbright Institute has generated the first pig antibodies against swine influenza (flu) that protect against infection and recognise the same parts of the flu virus as human antibodies. This indicates they could be used to develop and assess human antibody therapies and…