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T-cell cytokine response in Salmonella Typhimurium-vaccinated versus infected pigs

Vaccination with the live attenuated vaccine Salmoporc is an effective measure to control Salmonella Typhimurium (STM) in affected swine populations. However, the cellular immune response evoked by the Salmoporc vaccine including differences in vaccinated pigs versus non…

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Characteristics of Chlamydia suis ocular infection in pigs

Chlamydia (C.) suis can often be isolated from conjunctival swab specimens from pigs with conjunctivitis or keratoconjunctivitis. In the field, it is assumed to be a multifactorial disease triggered by immunosuppressing factors. This is the first experimental study to…

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Human-like response of pig T cells to superagonistic anti-CD28 monoclonal antibodies

Because of its size, anatomical similarities, and now also accessibility to genetic manipulations, pigs are used as animal models for human diseases and immune system development. However, expression and function of CD28, the most important costimulatory receptor expressed…

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Impact of specific N-glycan modifications on the use of plant-produced SARS-CoV-2 antigens in serological assays

The receptor binding domain (RBD) of the SARS-CoV-2 spike protein plays a key role in the virus-host cell interaction, and viral infection. The RBD is a major target for neutralizing antibodies, whilst recombinant RBD is commonly used as an antigen in serological assays…

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Haemagglutinin antigen selectively targeted to chicken CD83 overcomes interference from maternally derived antibodies in chickens

Maternally derived antibodies (MDAs) are important for protecting chickens against pathogens in the neonatal stage however, they often interfere with vaccine performance. Here, we investigated the effects of MDAs on a targeted antigen delivery vaccine (TADV), which is…

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Isolation, identification, and genomic characterization of chicken astrovirus isolates from China

Chicken astrovirus (CAstV) infection can cause diarrhea, nephritis, stunted growth, and “white chickens” condition, resulting in economic losses to the poultry industry. Currently, a few CAstVs were isolated and a few full-length genome sequences of CAstV have been deposited…

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Evaluation of electropolymerized molecularly imprinted polymers (E-MIPs) on disposable electrodes for detection of SARS-CoV-2 in saliva

We investigate electropolymerized molecularly imprinted polymers (E-MIPs) for the selective recognition of SARS-CoV-2 whole virus. E-MIPs imprinted with SARS-CoV-2 pseudoparticles (pps) were electrochemically deposited onto screen printed electrodes by reductive…

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SARS-CoV-2 variants can infect a wider range of animal cells according to new research led by Pirbright

SARS-CoV-2, the virus that causes COVID-19, can potentially infect a wider number of animal species including rodents and ferrets, reveal Pirbright scientists. The study found that SARS-CoV-2 variants Alpha, Beta and Delta can infect more species compared to the ancestral…

brown chickens with red combs

Research reveals even more benefits associated with the new bird flu vaccine developed at Pirbright

Pirbright scientists recently developed a potential bird flu vaccine that offered better protection to chickens. This vaccine was easier and less costly to produce than traditional flu vaccines. Researchers at the Institute have now discovered even more benefits from this…

Image of a cell infected with Mareks disease

Pirbright discovers ways to improve vaccine development and control of Marek’s disease virus

Research by Pirbright scientists reveals that the chicken immune response to Marek’s disease virus (MDV) differs depending on the genetic makeup of infected birds, with some chickens being more resistant to disease than others. MDV is a highly contagious virus that affects…