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The evolutionary pathway to virulence of an RNA virus

Paralytic polio once afflicted almost half a million children each year. The attenuated oral polio vaccine (OPV) has enabled world-wide vaccination efforts, which resulted in nearly complete control of the disease. However, poliovirus eradication is hampered globally by…

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Combining a universal capture ligand and pan-serotype monoclonal antibody to develop a pan-serotype lateral flow strip test for foot-and-mouth disease virus detection

Foot-and-mouth disease virus (FMDV) causes FMD, a highly contagious disease of cloven-hoofed animals including cattle, goats, pigs and sheep. Rapid detection of FMDV is critical to limit the devastating economic losses due to FMD. Current laboratory methods for FMDV…

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Porcine respiratory coronavirus as a model for acute respiratory coronavirus disease

In the light of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, we have developed a porcine respiratory coronavirus (PRCV) model for in depth mechanistic evaluation of the pathogenesis, virology and immune responses of this important family of…

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Porcine respiratory coronavirus as a model for acute respiratory coronavirus disease

In the light of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, we have developed a porcine respiratory coronavirus (PRCV) model for in depth mechanistic evaluation of the pathogenesis, virology and immune responses of this important family of…

default publication image

Porcine respiratory coronavirus as a model for acute respiratory coronavirus disease

In the light of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, we have developed a porcine respiratory coronavirus (PRCV) model for in depth mechanistic evaluation of the pathogenesis, virology and immune responses of this important family of…

default publication image

Porcine respiratory coronavirus as a model for acute respiratory coronavirus disease

In the light of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, we have developed a porcine respiratory coronavirus (PRCV) model for in depth mechanistic evaluation of the pathogenesis, virology and immune responses of this important family of…

default publication image

Porcine respiratory coronavirus as a model for acute respiratory coronavirus disease

In the light of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, we have developed a porcine respiratory coronavirus (PRCV) model for in depth mechanistic evaluation of the pathogenesis, virology and immune responses of this important family of…

default publication image

Porcine respiratory coronavirus as a model for acute respiratory coronavirus disease

In the light of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, we have developed a porcine respiratory coronavirus (PRCV) model for in depth mechanistic evaluation of the pathogenesis, virology and immune responses of this important family of…

default publication image

The pig as an amplifying host for new and emerging zoonotic viruses

Pig production is a rapidly growing segment of the global livestock sector, especially in Asia and Africa. Expansion and intensification of pig production has resulted in significant changes to traditional pig husbandry practices leading to an environment conducive to…

Pink piglet standing on gravel

Pirbright scientists investigate pig coronavirus infection to understand COVID-19 in humans

Researchers at Pirbright have developed a pig respiratory coronavirus (PRCV) model which will help to understand how coronaviruses cause disease and how the immune system responds to them. Human coronaviruses such as Middle East respiratory syndrome (MERS) and severe acute…