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Genome-wide SNP analysis identifies major QTL for Salmonella colonization in the chicken

Salmonella-infected poultry products are a major source of human Salmonella infection. The prophylactic use of antimicrobials in poultry production was recently banned in the EU, increasing the need for alternative methods to control Salmonella infections in poultry flocks…

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Foot-and-mouth disease marker vaccine: cattle protection with a partial VP1 G-H loop deleted virus antigen

Contrary to the dogma that the VP1 GH loop is essential for FMD vaccine efficacy, it has been previously shown that foot-and-mouth disease 146s antigen containing heterologous VP1 GH loops confers complete protection in pigs and cattle. Moreover, serological evaluation of…

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Immunization of knock-out ?/? interferon receptor mice against lethal bluetongue infection with a BoHV-4-based vector expressing BTV-8 VP2 antigen

New effective tools for vaccine strategies are necessary to limit the spread of bluetongue, an insect-transmitted viral disease of domestic and wild ruminants. In the present study, BoHV-4-based vector cloned as a bacterial artificial chromosome (BAC) was engineered to…

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Cytokine profiles and phenotype regulation of antigen presenting cells by genotype-I porcine reproductive and respiratory syndrome virus isolates

The present study examined the immunological response of antigen presenting cells (APC) to genotype-I isolates of porcine reproductive and respiratory syndrome virus (PRRSV) infection by analysing the cytokine profile induced and evaluating the changes taking place upon…

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Although divergent in residues of the peptide binding site, conserved chimpanzee Patr-AL and polymorphic human HLA-A*02 have overlapping peptide-binding repertoires

Patr-AL is an expressed, non-polymorphic MHC class I gene carried by ?50% of chimpanzee MHC haplotypes. Comparing Patr-AL+ and Patr-AL? haplotypes showed Patr-AL defines a unique 125-kb genomic block flanked by blocks containing classical Patr-A and pseudogene Patr-H…

Foot-and-mouth disease

Laboratory diagnosis of African swine fever (ASF): Instructor-led

Learn about ASFV isolation, diagnosis, serology, and characterisation techniques.

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Atmospheric dispersion models and their use in the assessment of disease transmission

Atmospheric dispersion models can be used to assess the likely airborne spread of both plant and animal diseases. These models, often initially developed for other purposes, can be adapted and used to study past outbreaks of disease as well as operationally to provide advice…

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Normal variation in thermal radiated temperature in cattle: implications for foot-and-mouth disease detection

Background: Thermal imagers have been used in a number of disciplines to record animal surface temperatures and as a result detect temperature distributions and abnormalities requiring a particular course of action. Some work, with animals infected with foot-and-mouth…

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Processing and localization of the African swine fever virus CD2v transmembrane protein

The African swine fever virus (ASFV)-encoded CD2v transmembrane protein is required for the hemadsorption of red blood cells around infected cells and is also required for the inhibition of bystander lymphocyte proliferation in response to mitogens. We studied the expression…

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Eimeria maxima phosphatidylinositol 4-phosphate 5-kinase: locus sequencing, characterization, and cross-phylum comparison

EimeriaPhosphatidylinositol 4-phosphate 5-kinase (PIP5K) may play an important role in host-cell invasion by the Eimeria species, protozoan parasites which can cause severe intestinal disease in livestock. Here, we report the structural organization of the PIP5K gene in…