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Alkhumra haemorrhagic fever virus

Alkhumra haemorrhagic fever virus (AHFV) is an emerging tick-borne zoonotic virus.

A glass model of foot and mouth disease virus in black and white

Centre for Veterinary Vaccine Innovation and Manufacturing (CVIM)

Accelerating the development and deployment of vaccines for neglected and emerging livestock and zoonotic diseases. Our governance CVIM is part of The Pirbright Institute but scientifically independent as reflected in our independent Chair for the Joint Oversight Committee…

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Wild boar visits to commercial pig farms in southwest England: implications for disease transmission

Contact between wild animals and farmed livestock may result in disease transmission with huge financial, welfare and ethical consequences. Conflicts between people and wildlife can also arise when species such as wild boar ( Sus scrofa) consume crops or dig up pasture. This…

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Wild boar visits to commercial pig farms in southwest England: implications for disease transmission

Contact between wild animals and farmed livestock may result in disease transmission with huge financial, welfare and ethical consequences. Conflicts between people and wildlife can also arise when species such as wild boar ( Sus scrofa) consume crops or dig up pasture. This…

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Marek's disease virus-specific T cells proliferate, express antiviral cytokines but have impaired degranulation response

The major histocompatibility complex (MHC) haplotype is one of the major determinants of genetic resistance and susceptibility of chickens to Marek's disease (MD) which is caused by an oncogenic herpesvirus; Marek's disease virus (MDV). To determine differential functional…

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Myeloid cell interferon secretion restricts Zika flavivirus infection of developing and malignant human neural progenitor cells

Zika virus (ZIKV) can infect human developing brain (HDB) progenitors resulting in epidemic microcephaly, whereas analogous cellular tropism offers treatment potential for the adult brain cancer, glioblastoma (GBM). We compared productive ZIKV infection in HDB and GBM…

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Myeloid cell interferon secretion restricts Zika flavivirus infection of developing and malignant human neural progenitor cells

Zika virus (ZIKV) can infect human developing brain (HDB) progenitors resulting in epidemic microcephaly, whereas analogous cellular tropism offers treatment potential for the adult brain cancer, glioblastoma (GBM). We compared productive ZIKV infection in HDB and GBM…

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Newcastle disease genotype VII prevalence in poultry and wild birds in Egypt

Newcastle Disease Virus (NDV) genotype VII is a highly pathogenic Orthoavulavirus that has caused multiple outbreaks among poultry in Egypt since 2011. This study aimed to observe the prevalence and genetic diversity of NDV prevailing in domestic and wild birds in Egyptian…

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Assessment of the impact of a toll-like receptor 2 agonist synthetic lipopeptide on macrophage susceptibility and responses to African swine fever virus infection

Toll-like receptor 2 (TLR2) ligands are attracting attention as prophylactic and immunopotentiator agents against pathogens, including viruses. We previously reported that a synthetic diacylated lipopeptide (Mag-Pam2Cys_P48) polarized porcine macrophages towards a…

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In vitro and in vivo antiviral activity of nucleoside analogue cHPMPC against African swine fever virus replication

African swine fever virus (ASFV) causes a haemorrhagic disease affecting wild boar and domestic pigs which can result in morbidity and fatality rates of up to 100%. ASFV is a large double-stranded DNA virus which replicates predominantly in the cell cytoplasm and codes for…