Research paper Virus and host factors affecting the clinical outcome of bluetongue virus infection Bluetongue is a major infectious disease of ruminants caused by bluetongue virus (BTV), an arbovirus transmitted by Culicoides. Here, we assessed virus and host factors influencing the clinical outcome of BTV infection using a single experimental framework. We investigated… Read more
Research paper Bluetongue, Schmallenberg virus ... African horse sickness? Following the incursions into the UK of bluetongue virus (BTV) in 2007 and Schmallenberg virus (SBV) in 2011, an increasingly pertinent question for those tasked with predicting and responding to outbreaks of livestock arboviruses in the UK is, what is next? Culicoides, the… Read more
Research paper Patterns of foot-and-mouth disease virus distribution in Africa: the role of livestock and wildlife in virus emergence Foot-and-mouth disease (FMD) is one of the most highly contagious diseases of animals. The disease is distributed on three continents (Asia, Africa and South America) where it disrupts the food security of people who depend on livestock and animal products. Substantial… Read more
Basic page Foot-and-mouth disease diagnostic reagents Bovine control serum, rabbit and guinea pig sera, inactivated antigens, NSP panel, ELISA kits, monoclonal antibodies. Read more
Research paper Expansion of anti-mesothelin specific CD4(+) and CD8(+) T cell responses in patients with pancreatic carcinoma We aimed to assess the status of naturally occurring CD4(+) and CD8(+) T cell responses to a tumour associated antigen, Mesothelin, in patients with pancreatic carcinoma and study the effects of elevated IL-10 on Mesothelin-specific T cell responses. For that sake, short… Read more
Research paper Different functions of the common P/V/W and V-specific domains of rinderpest virus V protein in blocking interferon signalling The V proteins of paramyxoviruses are composed of two evolutionarily distinct domains, the amino-terminal 75% being common to the viral P, V and W proteins and not highly conserved between viruses, while the remaining 25% consists of a cysteine-rich V-specific domain which… Read more
Research paper A B-cell targeting virus disrupts potentially protective genomic methylation patterns in lymphoid tissue by increasing global 5-hydroxmethylcytosine levels The mechanisms by which viruses modulate the immune system include changes in host genomic methylation. 5-hydroxmethylcytosine (5hmC) is the catalytic product of the Tet (Ten-11 translocation) family of enzymes and may serve as an intermediate of DNA demethylation. Recent… Read more
Research paper Development and validation of a 3ABC antibody ELISA in Australia for foot and mouth disease Objective: To measure the diagnostic performance of an Australian-developed ELISA for the detection of antibodies against the non-structural proteins (NSP) 3ABC of the foot and mouth disease (FMD) virus. Methods: The diagnostic specificity was determined using 2535 sera from… Read more
Research paper NKp46+CD3+ cells: a novel nonconventional T cell subset in cattle exhibiting both NK cell and T cell features The NKp46 receptor demonstrates a high degree of lineage specificity, being expressed almost exclusively in NK cells. Previous studies have demonstrated NKp46 expression by T cells, but NKp46+CD3+ cells are rare and almost universally associated with NKp46 acquisition by T… Read more
Research paper Immune characterization of long pentraxin 3 in pigs infected with influenza virus Long pentraxin 3 (PTX3) is a conserved pattern-recognition secreted protein and a hostdefence-related component of the humoral innate immune system. The aim of the present study was to characterize swine PTX3 (SwPTX3) protein expression in influenza virus infected pigs… Read more
