Research paper Recombinant vaccines against bluetongue virus Bluetongue (BT) is a hemorrhagic disease of ruminants caused by bluetongue virus (BTV), the prototype member of the genus Orbivirus within the family Reoviridae and is transmitted via biting midges of the genus Culicoides. BTV can be found on all continents except Antarctica… Read more
Research paper Vaccination of mice with a modified Vaccinia Ankara (MVA) virus expressing the African horse sickness virus (AHSV) capsid protein VP2 induces virus neutralising antibodies that confer protection against AHSV upon passive immunisation In previous studies we showed that a recombinant Modified Vaccinia Ankara (MVA) virus expressing the protein VP2 of AHSV serotype 4 (MVA-VP2) induced virus neutralising antibodies in horses and protected interferon alpha receptor gene knock-out mice (IFNAR?/?) against… Read more
Research paper Virus and host factors affecting the clinical outcome of bluetongue virus infection Bluetongue is a major infectious disease of ruminants caused by bluetongue virus (BTV), an arbovirus transmitted by Culicoides. Here, we assessed virus and host factors influencing the clinical outcome of BTV infection using a single experimental framework. We investigated… Read more
Research paper Bluetongue, Schmallenberg virus ... African horse sickness? Following the incursions into the UK of bluetongue virus (BTV) in 2007 and Schmallenberg virus (SBV) in 2011, an increasingly pertinent question for those tasked with predicting and responding to outbreaks of livestock arboviruses in the UK is, what is next? Culicoides, the… Read more
Research paper Patterns of foot-and-mouth disease virus distribution in Africa: the role of livestock and wildlife in virus emergence Foot-and-mouth disease (FMD) is one of the most highly contagious diseases of animals. The disease is distributed on three continents (Asia, Africa and South America) where it disrupts the food security of people who depend on livestock and animal products. Substantial… Read more
Basic page Foot-and-mouth disease diagnostic reagents Bovine control serum, rabbit and guinea pig sera, inactivated antigens, NSP panel, ELISA kits, monoclonal antibodies. Read more
Research paper Expansion of anti-mesothelin specific CD4(+) and CD8(+) T cell responses in patients with pancreatic carcinoma We aimed to assess the status of naturally occurring CD4(+) and CD8(+) T cell responses to a tumour associated antigen, Mesothelin, in patients with pancreatic carcinoma and study the effects of elevated IL-10 on Mesothelin-specific T cell responses. For that sake, short… Read more
Research paper Different functions of the common P/V/W and V-specific domains of rinderpest virus V protein in blocking interferon signalling The V proteins of paramyxoviruses are composed of two evolutionarily distinct domains, the amino-terminal 75% being common to the viral P, V and W proteins and not highly conserved between viruses, while the remaining 25% consists of a cysteine-rich V-specific domain which… Read more
Research paper A B-cell targeting virus disrupts potentially protective genomic methylation patterns in lymphoid tissue by increasing global 5-hydroxmethylcytosine levels The mechanisms by which viruses modulate the immune system include changes in host genomic methylation. 5-hydroxmethylcytosine (5hmC) is the catalytic product of the Tet (Ten-11 translocation) family of enzymes and may serve as an intermediate of DNA demethylation. Recent… Read more
Research paper Development and validation of a 3ABC antibody ELISA in Australia for foot and mouth disease Objective: To measure the diagnostic performance of an Australian-developed ELISA for the detection of antibodies against the non-structural proteins (NSP) 3ABC of the foot and mouth disease (FMD) virus. Methods: The diagnostic specificity was determined using 2535 sera from… Read more
