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Pirbright student wins Social Impact Award for COVID-19 work in Romania and UK

The COVID-19 pandemic has had a devastating impact on public health and the global economy. Vaccine rollouts, ongoing global research and test and trace programmes each play a crucial role in tackling the virus but so does increasing public knowledge and confidence in each…

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Porcine influenza mAbs to H3, H5, and H7 hemagglutinins recognize H3 egg adapted site and target the HA stem

Introduction Monoclonal antibodies (mAbs) are critical tools for elucidating viral evolution, informing vaccine design, and developing antiviral therapeutics. Large-animal models, such as the pig, that closely mirror human immune responses are essential for understanding…

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Diverse genomic landscape of swine influenza A virus in England (2014–2021)

Surveillance of swine influenza A viruses (SwIAVs) in pigs is critical for identification of novel genetic groups that pose a risk to pig health and might have zoonotic potential. SwIAVs circulating in pigs in England between 2014 and 2021 were characterized using whole…

Plowright and Jenner buildings at Pirbright against a blue sky

Funding strengthens Pirbright and Glasgow Centre for Virus Research partnership

The long-term partnership between The Pirbright Institute and MRC-University of Glasgow Centre for Virus Research (CVR) has been strengthened by a joint funding award of £500,000 from the Biotechnology and Biological Sciences Research Council (BBSRC). Pirbright and the CVR…

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Paraspeckle condensation is controlled via TDP-43 polymerization and linked to neuroprotection

The paraspeckle is a disease-relevant biomolecular condensate assembled from long non-coding RNA (lncRNA) NEAT1_2 ribonucleoprotein particles. Paraspeckle biogenesis is suppressed in normal tissues, yet it can be rapidly upregulated under stress. Here we demonstrate that a…

Two women on a lecture theatre stage (one with a face covering) holding a framed picture and glass trophy

Pirbright wins Openness Award for internal engagement activities on animal research

On Monday 6 December, The Pirbright Institute won the Internal Engagement category at the eighth annual Understanding Animal Research (UAR) Openness Awards for its exemplary approach to internal engagement practices, and its joined-up approach to research to ensure clarity…

Herd of goats

Pirbright research develops new vaccines that could contribute to the global eradication of peste des petits ruminants virus

Two new vaccine candidates that could differentiate between vaccinated and infected animals and contribute to the ongoing global eradication of peste des petits ruminants virus (PPRV) have been developed by researchers at The Pirbright Institute. Following the successful…

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Culicoides biting midges (Diptera: Ceratopogonidae) feeding on donkeys in the United Kingdom, with reference to the risk of transmission and persistence of African horse sickness virus

African horse sickness virus (AHSV: Sedoreoviridae; Orbivirus) causes a severe and often fatal disease in horses (African horse sickness: AHS) and is transmitted almost exclusively by Culicoides biting midges (Diptera: Ceratopogonidae). In recent years, unprecedented…

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Panalyze: automated virus pangenome variation graph construction, analysis and annotation

Motivation Constructing and studying pangenome variation graphs (PVGs) supports new insights into viral genomic diversity. This is because such pangenomes are less prone to reference bias, which affects mutation detection. Interpreting the information arising from this is…

Chickens scratching in grass

Avian influenza: tackling large numbers of outbreaks this winter in the UK

Nearly two years on, the COVID-19 pandemic is still dominating the news and continues to cause concern for populations across the globe. However, UK poultry and wild bird populations are currently facing their own health threat. We are not the only ones that have faced…