Search | The Pirbright Institute

Filters

default publication image

Regulatory mechanism of DNMT3A in interferon expression inhibition by Newcastle disease virus V protein

Newcastle disease (ND), caused by the Newcastle disease virus (NDV) and characterised by rapid onset and high mortality rates, is a highly contagious disease in the poultry industry. Interferons (IFN) play a key role in host defence against NDV, however, the non-structural…

Flourescence image of rinderpest

Genetic analysis of rinderpest by Pirbright scientists reveals new information

Scientists at The Pirbright Institute have shed new light on the genetics, evolution and spread of rinderpest by analysing the genetic sequences of the stocks destroyed at the Rinderpest Holding Facility and World Reference Laboratory for rinderpest held at Pirbright. In…

default publication image

Investigating the RelA Gene's role in African Swine fever tolerance: a study of Indian pigs

African Swine Fever (ASF) is a highly contagious transboundary viral disease affecting domestic pigs worldwide, often resulting in nearly 100 % mortality due to the lack of effective vaccines. However, wild species such as warthogs (Phacochoerus sp.) and bush pigs…

default publication image

An antigen panel to assess the regional relevance of foot and mouth disease vaccines

Despite widespread use of inactivated vaccines to control foot-and-mouth disease (FMD), there is no systematic approach to demonstrate the regional relevance of these products against the specific serotypes and strains that circulate in endemic countries in Africa and Asia…

Sheep being moved across the plains in Mongolia by nomadic herders

Pirbright calculates impact of foot-and-mouth disease control in Mongolia

Researchers at The Pirbright Institute have collaborated with State Central Veterinary Laboratories (SCVL) and the General Agency for Veterinary Services (GAVS) in Mongolia to assess the impact of foot-and-mouth disease (FMD) control methods employed during the 2017…

default publication image

Foot-and-mouth disease virus O/ME-SA/SA-2018: A new emerging threat posed by viruses circulating in Asia?

In 2018, a novel lineage of foot-and-mouth disease virus (FMDV) termed O/ME-SA/SA-2018 was identified in India, which subsequently spread into neighbouring countries (Nepal, Bangladesh and Sri Lanka). Since then, incursions of this lineage have occurred in the Middle East…

default publication image

Estimating population immunity to SARS-CoV-2 by random sampling from primary and secondary healthcare in Scotland, May 2024

Background: As the COVID-19 pandemic has ended, the global focus has shifted from "pandemic response" to "long-term management". With no ongoing nationwide serosurveillance studies, our understanding of the level of immunity in the general population has diminished. In this…

Female pig in hay inside

Pirbright African swine fever vaccine protects 100% of pigs from developing severe disease

Scientists from The Pirbright Institute are a step closer in the race to develop a vital vaccine for African swine fever (ASF). In their recent trial, published in Vaccines, 100 percent of pigs immunised with the new vaccine survived a lethal dose of ASF virus. ASF causes…

default publication image

Proliferation makes a substantive contribution to the maintenance of airway resident memory T-cell subsets in young pigs

Tissue-resident memory (TRM) T cells play an important role in protection against respiratory infection but whether this memory is maintained by long-lived or dividing cells remains controversial. To address the rate of division of lung TRM T cells, deuterium-enriched water…

default publication image

Vaccination and surveillance for high pathogenicity avian influenza in poultry-current situation and perspectives

The International Alliance for Biological Standardization (IABS), in collaboration with the World Organization for Animal Health (WOAH) convened a hybrid meeting on 22-23 October 2024 at the WOAH Headquarters (HQ) in Paris, France to discuss the global state of vaccination…