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Turnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress

The integrated stress response (ISR) is a key cellular signaling pathway activated by environmental alterations that represses protein synthesis to restore homeostasis. To prevent sustained damage, the ISR is counteracted by the upregulation of growth arrest and DNA damage…

map of Asia

Pirbright research to tackle Asian viruses

The Pirbright Institute has been awarded over £1million by the BBSRC-Newton Fund to tackle four major viral diseases that threaten livestock populations across Asia. Pirbright scientists will study two poultry and two pig diseases that have a severe impact on the wellbeing…

Flock of white sheep on grass. A long line of them extends into the background down a slope

Pirbright shares award to make affordable anti-parasite vaccine

Scientists at the Moredun Research Institute, near Edinburgh, and The Pirbright Institute have been awarded a £1.7 million grant over three years by the Bill & Melinda Gates Foundation to develop a vaccine against a life-threatening parasite of sheep and goats. The parasite…

Flu graphic - inside the virus

Pirbright to research how rapidly bird flu can adapt to infect humans

Scientists at The Pirbright Institute and Imperial College London have been awarded a grant by the Biotechnology and Biological Sciences Research Council (BBSRC) to research what makes particular strains of bird flu more likely to adapt to mammalian hosts, and possibly…

Close up of pink pig face snoozing on straw

Pirbright’s pig immunology expertise advances cystic fibrosis research

A pig model is enhancing cystic fibrosis research.

Cows in a field at Pirbright Compton site

Pirbright helps demonstrate the UK remains free from bluetongue virus

Scientists at The Pirbright Institute have played a key role in providing assurance that the UK remains free from bluetongue following the positive test results of four cattle which had moved from France into the north of England and Scotland in October 2017 without…

Two mosquitoes laid out facing each other

Insect transgenesis

Generating genetically modified insects to uncover virus-vector interactions.

White chicken

Poultry keepers need to be vigilant to combat the spread of bird flu in the UK

The recent H5N6 bird flu outbreak is confined to the south of England, partly due to the introduction of an Avian Influenza Protection Zone in England and Wales including strict biosecurity measures for affected bird keepers. But what is bird flu? Why is it such a threat…

Cells infected with African swine fever

Advance in the hunt for African swine fever vaccine

Researchers from The Pirbright Institute have made a promising step forward by identifying key African swine fever virus (ASFV) proteins that induce immune responses in pigs. ASFV is an extremely severe and economically important disease of domestic pigs, which is usually…

foot-and-mouth disease infected cell

Foot-and-mouth disease protein could be used for disease detection

Dr Stephen Berryman and Dr Toby Tuthill from The Pirbright Institute have collaborated with the MRC Laboratory of Molecular Biology and other research institutes* to uncover a new system used by the foot-and-mouth disease virus (FMDV) to prevent antiviral signalling of…