Search | The Pirbright Institute

Filters

default publication image

Identification of the genome segments of bluetongue virus serotype 26 (isolate KUW2010/02) that restrict replication in a Culicoides sonorensis cell line (KC cells)

Bluetongue virus (BTV) can infect most ruminant species and is usually transmitted by adult, vector-competent biting midges (Culicoides spp.). Infection with BTV can cause severe clinical signs and can be fatal, particularly in naïve sheep and some deer species. Although 24…

default publication image

Introduction and enzootic of A/H5N1 in Egypt: Virus evolution, pathogenicity and vaccine efficacy ten years on

It is almost a decade since the highly pathogenic H5N1 avian influenza virus (A/H5N1) of clade 2.2.1 was introduced to Egypt in 2005, most likely, via wild birds; marking the longest endemic status of influenza viruses in poultry outside Asia. The endemic A/H5N1 in Egypt…

default publication image

1α,25(OH)2 vitamin D3 modulates avian T lymphocyte functions without inducing CTL unresponsiveness

1,25-Dihydroxyvitamin D3 (Vitamin D) is a naturally synthesized fat soluble vitamin shown to have immunomodulatory, anti-inflammatory and cancer prevention properties in human and murine models. Here, we studied the effects of Vitamin D on the functional abilities of avian T…

default publication image

Real-time PCR for differential quantification of CVI988 vaccine virus and virulent strains of Mareks disease virus

CVI988/Rispens vaccine, the gold standard vaccine against Mareks disease in poultry, is not easily distinguishable from virulent strains of Mareks disease herpesvirus (MDV). Accurate differential measurement of CVI988 and virulent MDV is commercially important to confirm…

default publication image

Using shared needles for subcutaneous inoculation can transmit bluetongue virus mechanically between ruminant hosts

Bluetongue virus (BTV) is an economically important arbovirus of ruminants that is transmitted by Culicoides spp. biting midges. BTV infection of ruminants results in a high viraemia, suggesting that repeated sharing of needles between animals could result in its iatrogenic…

default publication image

Experimental infection of Ornithodoros erraticus sensu stricto with two Portuguese African swine fever virus strains. Study of factors involved in the dynamics of infection in ticks

African swine fever (ASF) is a frequently devastating hemorrhagic disease of domestic pigs and wild boar and Ornithodoros erraticus sensu stricto argasid ticks are the only biological vectors of African swine fever virus (ASFV) known to occur in Europe. Recently this disease…

default publication image

Efficient generation of vesicular stomatitis virus (VSV)-pseudotypes bearing morbilliviral glycoproteins and their use in quantifying virus neutralising antibodies

Morbillivirus neutralising antibodies are traditionally measured using either plaque reduction neutralisation tests (PRNTs) or live virus microneutralisation tests (micro-NTs). While both test formats provide a reliable assessment of the strength and specificity of the…

Pirbright scientists inspire at Innovate

On Saturday 12 March 2016, scientists from Pirbright headed to Innovate Guildford – a free festival of science and arts, where they showcased their research on influenza and insects. The Innovate Guildford science and arts festival is part of the Mayor of Guildford…

default publication image

Mass vaccination, immunity and coverage: modelling population protection against foot-and-mouth disease in Turkish cattle

Foot-and-mouth disease (FMD) in Turkey is controlled using biannual mass vaccination of cattle. However, vaccine protection is undermined by population turnover and declining immunity. A dynamic model of the Turkish cattle population was created. Assuming biannual mass…

default publication image

The non-structural protein 5 and matrix protein are antigenic targets of T cell immunity to genotype 1 porcine reproductive and respiratory syndrome viruses

The porcine reproductive and respiratory syndrome virus (PRRSV) is the cause of one of the most economically important diseases affecting swine worldwide. Efforts to develop a next-generation vaccine have largely focused on envelope glycoproteins to target virus-neutralizing…