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FMD vaccine matching: inter laboratory study for improved understanding of r1 values

Foot-and-mouth disease virus (FMDV) is a highly variable RNA virus existing as seven different serotypes. The antigenic variability between and within serotypes can limit the cross-reactivity and therefore the in vivo cross-protection of vaccines. Selection of appropriate…

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Differential expression of immune-related genes in the bursa of Fabricius of two inbred chicken lines following infection with very virulent infectious bursal disease virus

Among different inbred chickens' lines, we previously showed that lines P and N of Institute for Animal Health, Compton, UK are the most susceptible and the least affected lines, respectively, following infection with very virulent infectious bursal disease virus (vvIBDV)…

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Post-vaccination herd immunity against peste des petits ruminants and inter-vaccination population turnover in small ruminant flocks in northwest Ethiopia

Vaccination is the main tool for control of peste des petits ruminants (PPR) because of the availability of effective and safe vaccines that provide long lasting protection. However vaccination campaigns may not always provide sufficient herd immunity needed to prevent…

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Nomenclature report for killer-cell immunoglobulin-like receptors (KIR) in macaque species: new genes/alleles, renaming recombinant entities and IPD-NHKIR updates

The Killer-cell Immunoglobulin-like Receptors (KIR) are encoded by a diverse group of genes, which are characterized by allelic polymorphism, gene duplications, and recombinations, which may generate recombinant entities. The number of reported macaque KIR sequences is…

World Organisation for Animal Health (OIE) confirms IAH experts

The Institute’s Dr Michael Baron and Dr Chris Oura have been confirmed as OIE Experts on rinderpest/peste des petits ruminants and African horse sickness/bluetongue, respectively, following the OIE’s 79th General Session in Paris in May. IAH contains Reference Laboratories –…

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Identification and characterisation of a Masculinizer homolog in the diamondback moth Plutella xylostella

Recently, a novel sex-determination system was identified in the silkworm ( Bombyx mori) in which a piRNA encoded on the female-specific W chromosome silences a Z-linked gene ( Masculinizer) which would otherwise initiate male sex-determination and dosage compensation…

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Binomial nomenclature for virus species: a consultation

The Executive Committee of the International Committee on Taxonomy of Viruses (ICTV) recognizes the need for a standardized nomenclature for virus species. This article sets out the case for establishing a binomial nomenclature and presents the advantages and disadvantages…

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Development of a RACE-based RNA-Seq approach to characterize the T-cell receptor repertoire of porcine gammadelta T cells

Recent data suggest that porcine gammadelta T cells exhibit a similar degree of functional plasticity as human and murine gammadelta T cells. Due to the high frequency of TCR-gammadelta + cells in blood and secondary lymphatic organs, the pig is an attractive model to study…

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Serum anti-neuraminidase antibody responses in human influenza A(H1N1)pdm09 virus infections

Haemagglutination inhibition (HAI) antibody titres are a correlate of protection for influenza virus infection, but several studies have also demonstrated the protective role of anti-neuraminidase (anti-NA) antibodies. However, there is limited data on anti-NA antibody…

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Neuraminidase activity and specificity of influenza A virus are influenced by haemagglutinin-receptor binding

Influenza virus haemagglutinin (HA) and neuraminidase (NA) are involved in the recognition and modulation of sialic acids on the cell surface as the virus receptor. Although the balance between two proteins functions has been found to be crucial for viral fitness, the…