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Bug Busters at Innovate Guildford 2018

Bugs and beasties spread diseases at Innovate Guildford

On Saturday 17 March 2018, Pirbright’s team of Bug Busters were at Innovate Guildford showcasing the Institute’s research on genetic engineering and how the technology can be used help fight devastating diseases spread by mosquitoes. Innovate Guildford is a science and arts…

The Biggs Avian Research Building

The Biggs Avian Research Building

A low-containment facility for poultry and small animal research.

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Blood-feeding, susceptibility to infection with Schmallenberg virus and phylogenetics of Culicoides (Diptera: Ceratopogonidae) from the United Kingdom

Culicoides biting midges (Diptera: Ceratopogonidae) are responsible for the biological transmission of internationally important arboviruses of livestock. In 2011, a novel Orthobunyavirus was discovered in northern Europe causing congenital malformations and abortions in…

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The role of Culex pipiens L. (Diptera: Culicidae) in virus transmission in Europe

Over the past three decades, a range of mosquito-borne viruses that threaten public and veterinary health have emerged or re-emerged in Europe. Mosquito surveillance activities have highlighted the Culex pipiens species complex as being critical for the maintenance of a…

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Recent advances in veterinary applications of structural vaccinology

The deployment of effective veterinary vaccines has had a major impact on improving food security and consequently human health. Effective vaccines were essential for the global eradication of Rinderpest and the control and eradication of foot-and-mouth disease in some…

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Evaluating the most appropriate pooling ratio for EDTA blood samples to detect bluetongue virus using real-time RT-PCR

The control of Bluetongue virus (BTV) presents a significant challenge to European Union (EU) member states as trade restrictions are placed on animals imported from BTV-affected countries. BTV surveillance programs are costly to maintain, thus, pooling of EDTA blood samples…

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Evaluating the most appropriate pooling ratio for EDTA blood samples to detect bluetongue virus using real-time RT-PCR

The control of Bluetongue virus (BTV) presents a significant challenge to European Union (EU) member states as trade restrictions are placed on animals imported from BTV-affected countries. BTV surveillance programs are costly to maintain, thus, pooling of EDTA blood samples…

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Infection of monocytes with European porcine reproductive and respiratory syndrome virus (PRRSV-1) strain Lena is significantly enhanced by dexamethasone and IL-10

Monocytes are considered refractory to porcine reproductive and respiratory syndrome virus type 1 (PRRSV-1) infection. However, monocytes are only short-lived in blood, being able to differentiate into macrophages and dendritic cells (DC). It was therefore merited to revisit…

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Establishment of a bovine viral diarrhea virus type 2 intranasal challenge model for assessing vaccine efficacy

The objective of this study was to develop a bovine viral diarrhea virus type 2 (BVDV-2) challenge model suitable for evaluation of efficacy of BVDV vaccines; a model that mimics natural infection and induces clear leukopenia and viremia. Clinical, hematological and…

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Efficacy of a high-potency multivalent foot-and-mouth disease virus vaccine in cattle against heterologous challenge with a field virus from the emerging A/ASIA/G-VII lineage

In 2015, outbreaks of foot-and-mouth disease (FMD) in the Middle East were discovered to be caused by a viral lineage (A/ASIA/G-VII), which has recently emerged from the Indian sub-continent. In vitro vaccine matching data generated by the World Reference Laboratory (WRLFMD)…