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Functional alleles of chicken BG genes, members of the butyrophilin gene family, in peripheral T cells

γδ T cells recognize a wide variety of ligands in mammals, among them members of the butyrophilin (BTN) family. Nothing is known about γδ T cell ligands in chickens, despite there being many such cells in blood and lymphoid tissues, as well as in mucosal surfaces. The major…

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Comparison of heterosubtypic protection in ferrets and pigs induced by a single cycle influenza vaccine

Influenza is a major health threat, and a broadly protective influenza vaccine would be a significant advance. Signal Minus FLU (S-FLU) is a candidate broadly protective influenza vaccine that is limited to a single cycle of replication, which induces a strong cross-reactive…

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Chicken interferon-induced protein with tetratricopeptide repeats 5 antagonizes replication of RNA viruses

The intracellular actions of interferon (IFN)-regulated proteins, including IFN-induced proteins with tetratricopeptide repeats (IFITs), attribute a major component of the protective antiviral host defense. Here we applied genomics approaches to annotate the chicken IFIT…

Dr Erica Bickerton egg candling

New method for infectious bronchitis vaccine production funded

Scientists at The Pirbright Institute have been awarded over £300,000 to develop a faster and more efficient method for infectious bronchitis virus (IBV) vaccine production. The virus causes a poultry respiratory disease which is the most economically important infectious…

African domestic cows in Tanzania

Pirbright identifies two new genetic groups of foot-and-mouth disease virus

Researchers from The Pirbright Institute have examined the genetic material of foot-and-mouth disease virus (FMDV) samples collected from eastern and southern Africa, and discovered two novel virus groups. These new groups, termed genotypes, will help scientists to…

Cell Infected with PPRV Under the Microscope

Viral collections

Our reference laboratories maintain collections of characterised viruses which can be supplied to researchers.

Immunological Toolbox

Immunological toolbox

A comprehensive resource advancing veterinary immunology.

Bird on shavings

Animal lines

Genetically distinct inbred lines of chickens, pigs, and MHC-defined cattle offer crucial models for studying host-pathogen interactions and advancing disease control.

DNA

Bioinformatics

Delivering high-containment sequencing, bespoke analysis, and innovative tools to advance animal virology research.

Flow cytometry and cell sorting

Flow cytometry

Offering advanced instrumentation and cell sorting services for the analysis of livestock samples.