Search | The Pirbright Institute

Filters

default publication image

The role of Toll-like receptors in the host response to viruses

The discovery of Toll-like receptors (TLR) has revolutionised our understanding of innate immunity. Numerous reviews have been written on the subject in the past few years. Here, we review the evidence that TLRs are involved in sensing and initiating anti-viral responses…

default publication image

Evasion of innate immunity by vaccinia virus

Vaccinia virus, a member of the Poxviridae, expresses many proteins involved in immune evasion. In this review, we present a brief characterisation of the virus and its effects on host cells and discuss representative secreted and intracellular proteins expressed by vaccinia…

default publication image

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence

Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses. Here, we define the function of the vaccinia virus (VV) protein A46R and show it…

default publication image

The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense

Toll-like receptors (TLRs) are crucial in the innate immune response to pathogens, in that they recognize and respond to pathogen associated molecular patterns, which leads to activation of intracellular signaling pathways and altered gene expression. Vaccinia virus (VV)…

default publication image

Identification of a bisegmented double-stranded RNA Virus (Picobirnavirus) in faeces of giant anteaters (Myrmecophaga tridactyla)

default publication image

Modulation of type I interferon signaling by African swine fever virus (ASFV) of different virulence L60 and NHV in macrophage host cells

ASFV causes an important disease of domestic swine and wild boar. Currently no vaccine is available, highlighting the necessity to understand ASFV modulation of innate immune responses in natural host cells. With this aim, macrophage cultures enriched in SWC9 and CD163…

default publication image

NDV entry into dendritic cells through macropinocytosis and suppression of T lymphocyte proliferation

Newcastle disease virus (NDV) causes major economic losses in the poultry industry. Previous studies have shown that NDV utilizes different pathways to infect various cells, including dendritic cells (DCs). Here, we demonstrate that NDV gains entry into DCs mainly via…

Towards a universal influenza vaccine

Researchers at The Pirbright Institute, which receives strategic funding from BBSRC, in collaboration with colleagues at the University of Oxford working together as the Jenner Institute, have taken an important step towards a universal vaccine against avian influenza. This…

default publication image

The immunogenicity of recombinant vaccines based on modified Vaccinia Ankara (MVA) viruses expressing African horse sickness virus VP2 antigens depends on the levels of expressed VP2 protein delivered to the host

African horse sickness (AHS) is a lethal equine disease transmitted by Culicoides biting midges and caused by African horse sickness virus (AHSV). AHS is endemic to sub-Saharan Africa, but devastating outbreaks have been recorded periodically outside this region. The…

default publication image

Therapeutic administration of broadly neutralizing FI6 antibody reveals lack of interaction between human IgG1 and Pig Fc Receptors

Influenza virus infection is a significant global health threat. Because of the lack of cross-protective universal vaccines, short time window during which antivirals are effective and drug resistance, new therapeutic anti-influenza strategies are required. Broadly, cross…