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Characterization of the interaction of African swine fever virus with monocytes and derived macrophage subsets

African swine fever (ASF) is a devastating disease for which there is no vaccine available. The ASF virus (ASFV) primarily infects cells of the myeloid lineage and this tropism is thought to be crucial for disease pathogenesis. A detailed in vitro characterization of the…

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Picornavirus RNA is protected from cleavage by ribonuclease during virion uncoating and transfer across cellular and model membranes

Picornaviruses are a large family of important human and animal pathogens that include poliovirus, human rhinovirus and foot-and-mouth disease virus. Picornaviruses enter the host cell by hijacking one of the vesicle-mediated cellular entry routes. However, once the virus is…

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Concrete pouring ceremony for The Pirbright Institute’s new laboratory facility

A concrete pouring ceremony has been held at The Pirbright Institute to mark the start of construction of new medium containment laboratories. Funded by UK Government via the Biotechnology and Biological Sciences Research Council (BBSRC), the £15.4million building is part of…

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Investigation of the role of protein kinase D in human rhinovirus replication

Picornavirus replication is known to cause extensive remodelling of Golgi and endoplasmic reticulum membranes and a number of the host proteins involved in the viral replication complex have been identified, including oxysterol binding protein (OSBP) and phosphatidylinositol…

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Frequency and phenotype of NK cells and NK cell subsets in bovine lymphoid compartments and blood

NK cells are widely distributed in lymphoid and non-lymphoid tissues however little is known about the recirculation of NK cells between blood and tissues. This is relevant to understanding recirculation in the steady-state and also for determining the roles for NK cells in…

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Towards the genetic control of invasive species

Invasive species remain one of the greatest threats to global biodiversity. Their control would be enhanced through the development of more effective and sustainable pest management strategies. Recently, a novel form of genetic pest management (GPM) has been developed in…

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Feline immunodeficiency virus cross-species transmission: Implications for emergence of new lentiviral infections

Owing to a complex history of host-parasite coevolution, lentiviruses exhibit a high degree of species specificity. Given the well-documented viral archeology of HIV emergence following human exposures to SIV, understanding processes that promote successful cross-species…

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Initiation of primary cell cultures from embryonic Haemaphysalis bispinosa ticks

Tick cell cultures have been widely used as an important tool for the study of tick-associated microorganisms, specifically for medically important bacteria or viruses that may be difficult to isolate or culture in axenic conditions. In this study, primary embryonic tick…

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Concurrent infection of bluetongue and peste-des-petits-ruminants virus in small ruminants in Haryana State of India

Bluetongue (BT) and peste-des-petits-ruminants (PPR) are major transboundary diseases of small ruminant, which are endemic in India. Testing of bluetongue virus (BTV) and peste-des-petits-ruminants virus (PPRV) from recent outbreaks (20152016) in different regions of…

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IPD-MHC 2.0: an improved inter-species database for the study of the major histocompatibility complex

The IPD-MHC Database project ( http://www.ebi.ac.uk/ipd/mhc/) collects and expertly curates sequences of the major histocompatibility complex from non-human species and provides the infrastructure and tools to enable accurate analysis. Since the first release of the database…