Research paper Environmental effects on protection against Mycobacterium tuberculosis after immunization with Ad85A Previously we have shown that intradermal (i.d.) immunization with a recombinant adenovirus expressing antigen 85A (Ad85A) induced a strong splenic CD8 T cell response in BALB/c mice but a weak lung immune response and did not protect mice against challenge with… Read more
Research paper Evolutionary dynamics of bovine coronaviruses: natural selection pattern of the spike gene implies adaptive evolution of the strains Coronaviruses demonstrate great potential for interspecies transmission, including zoonotic outbreaks. Although bovine coronavirus (BCoV) strains are frequently circulating in cattle farms worldwide, causing both enteric and respiratory disease, little is known about their… Read more
Research paper Characterization of ovine Nectin-4, a novel peste des petits ruminants virus receptor Small ruminants infected with peste des petits ruminants virus exhibit lesions typical of epithelial infection and necrosis. However, the only established host receptor for this virus is the immune cell marker signaling lymphocyte activation molecule (SLAM). We have… Read more
Research paper Marek's disease in commercial turkey flocks (letter) Marek's disease (MD) is a disease of herpesviral aetiology that causes immunosuppression and formation of tumours in many organ systems, primarily in chickens. The causative agent, Marek's disease virus (MDV), has been shown to regularly infect commercial chicken operations… Read more
Research paper The short stalk length of highly pathogenic avian influenza H5N1 virus neuraminidase limits transmission of pandemic H1N1 virus in ferrets H5N1 influenza viruses pose a pandemic threat but have not acquired the ability to support sustained transmission between mammals in nature. The restrictions to transmissibility of avian influenza viruses in mammals are multigenic, and overcoming them requires adaptations in… Read more
Research paper A new model for CD8(+) t cell memory inflation based upon a recombinant adenoviral vector CD8(+) T cell memory inflation, first described in murine CMV (MCMV) infection, is characterized by the accumulation of high-frequency, functional Ag-specific CD8(+) T cell pools with an effector-memory phenotype and enrichment in peripheral organs. Although persistence of… Read more
Research paper Evaluation and use of in-silico structure-based epitope prediction with foot-and-mouth disease virus Understanding virus antigenicity is of fundamental importance for the development of better, more cross-reactive vaccines. However, as far as we are aware, no systematic work has yet been conducted using the 3D structure of a virus to identify novel epitopes. Therefore we… Read more
Basic page Diagnostic testing How to request virus diagnostic services from our reference laboratories. Read more
Research paper Induction of CD152 (CTLA-4) and LAP (TGF-beta 1) in human Foxp3(-) CD4(+) CD25(-) T cells modulates TLR-4 induced TNF-alpha production CD152 (CTLA-4) is a co-stimulatory molecule that is expressed by T cells and negatively regulates immune responses. Here, we report the identification of a novel ligand. GPC(81-95), with the ability to induce both CD152 and LAP (TGF-beta 1) on human Foxp3(-) CD25(-) CD4(+) T… Read more
Research paper Bluetongue virus reverse genetics This chapter contains sections titled: Introduction to Bluetongue virus, Bluetongue virus replication, Reverse genetics, Uses of reverse genetics in orbivirus research, Future perspectives. Read more
