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A genome assembly and transcriptome atlas of the inbred Babraham pig to illuminate porcine immunogenetic variation

The inbred Babraham pig serves as a valuable biomedical model for research due to its high level of homozygosity, including in the major histocompatibility complex (MHC) loci and likely other important immune-related gene complexes, which are generally highly diverse in…

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The 2024 IPD-MHC database update: a comprehensive resource for major histocompatibility complex studies

The IPD-MHC Database project (http://www.ebi.ac.uk/ipd/mhc/) serves as a comprehensive and expertly curated repository for major histocompatibility complex (MHC) sequences from non-human species, providing the necessary infrastructure and tools to study the function and…

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Undiagnosed West Nile virus lineage 2d infection in a febrile patient from South-west Uganda, 2018

We report the retrospective identification and subsequent recovery of a near-complete West Nile Virus lineage 2 genomes from a hospitalized patient with acute febrile illness in Uganda, using a combination of degenerate primer polymerase chain reaction screening and a novel…

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Expression of key immune genes in polarized porcine monocyte-derived macrophage subsets

Swine are considered one of the most relevant large animal biomedical models since they share many immunological similarities with humans. Despite that, macrophage polarization has not comprehensively investigated in pigs. In this study, porcine monocyte-derived macrophages…

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Environmental sampling for the detection of capripox viruses and peste des petits ruminants virus in households and livestock markets in Plateau State, Nigeria

Multiple transboundary animal diseases (TADs) circulate in Plateau State, Nigeria, where livestock keeping is common and contributes to both the physical and socio-economic well-being of a large proportion of the population. In this study, we explored the potential for…

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Pirbright appoints new science leaders

Two scientific specialists have been appointed to new roles at The Pirbright Institute. Dr Georgina Limon-Vega has been promoted to Group Leader in Applied Epidemiology. Georgina studied Veterinary Medicine at the National Autonomous University of Mexico (UNAM) and holds a…

FMDV antibody discovery could aid vaccine development

Scientists have discovered a universal antibody that could help vaccine developers tackle foot-and-mouth disease virus (FMDV). Causing a highly contagious disease with high economic impact, FMDV affects susceptible cloven-hooved animals and fatalities may occur in young…

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Sharing animal expertise

Animal technicians from The Pirbright Institute and the Animal and Plant Health Agency (APHA) are collaborating to share expertise and best practice in animal care. The teams, who specialise in large animals, are exchanging information and learned experience on issues…

Biorisk advisor training

Learn the essentials for managing biosafety risks in biological containment labs.

Process Safety Through Failure Mode and Effect Analysis FMEA: eLearning

Learn how to conduct a Failure Mode and Effect Analysis (FMEA) exercise.