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Research paper

Cell entry mechanisms of African swine fever virus

African swine fever virus (ASFV) is a highly complex virus that poses a significant threat to the global swine industry. However, little is known about the mechanisms of ASFV cell entry because ASFV has a multilayered structure and a genome encoding over 150 proteins. This…
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Research paper

Undiagnosed West Nile virus lineage 2d infection in a febrile patient from South-west Uganda, 2018

We report the retrospective identification and subsequent recovery of a near-complete West Nile Virus lineage 2 genomes from a hospitalized patient with acute febrile illness in Uganda, using a combination of degenerate primer polymerase chain reaction screening and a novel…
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Research paper

Using the basic reproduction ratio to quantify transmission and identify data gaps for epizootic haemorrhagic disease virus

Epizootic haemorrhagic disease virus (EHDV) is an arbovirus transmitted by Culicoides biting midges that has recently emerged in Europe. Here, the basic reproduction ratio (R0) was used to quantify the transmission of EHDV and its dependence on temperature for cattle and…
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Pig sniffing at apple
Article

Outbred pigs can serve as model for human therapeutics

Laboratory-made monoclonal antibodies are used to treat conditions including cancer, autoimmune and infectious diseases. Commercial outbred pigs can be used as models to test how quickly therapeutic monoclonal antibodies (mAbs) disappear from the human body after injection…
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Article

Emerging threat: Study reveals gaps in knowledge about EHDV transmission in Europe

A new study highlights significant gaps in our understanding of the transmission dynamics of epizootic haemorrhagic disease virus (EHDV) which primarily infects cattle and deer. EHDV was detected in Europe for the first time in 2022, with outbreaks reported in Italy and…
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Research paper

Activation of the mitochondrial unfolded protein response regulates the dynamic formation of stress granules

To rapidly adapt to harmful changes to their environment, cells activate the integrated stress response (ISR). This results in an adaptive transcriptional and translational rewiring, and the formation of biomolecular condensates named stress granules (SGs), to resolve stress…
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Research paper

Assessment of PPMV-1 Genotype VI Virulence in Pigeons and Chickens and Protective Effectiveness of Paramyxovirus Vaccines in Pigeons

Pigeon paramyxovirus serotype 1 (PPMV-1), an antigenic and host variant of avian paramyxovirus Newcastle disease virus (NDV), primarily originating from racing pigeons, has become a global panzootic. Egypt uses both inactivated PPMV-1 and conventional NDV vaccines to protect…
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Three photos of Munir, Don and Georgina at lecterns presenting
Article

Pirbright expertise supporting control of livestock diseases in North Africa

Three scientists from The Pirbright Institute have shared their knowledge of tackling animal viruses at a North African conference. Professor Munir Iqbal, Dr Donald King and Dr Georgina Limon-Vega addressed an audience of vets and representatives from animal health…
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Three photos of Munir, Don and Georgina at lecterns presenting
Article

Pirbright expertise supporting control of livestock diseases in North Africa

Three scientists from The Pirbright Institute have shared their knowledge of tackling animal viruses at a North African conference. Professor Munir Iqbal, Dr Donald King and Dr Georgina Limon-Vega addressed an audience of vets and representatives from animal health…
Read more
Three photos of Munir, Don and Georgina at lecterns presenting
Article

Pirbright expertise supporting control of livestock diseases in North Africa

Three scientists from The Pirbright Institute have shared their knowledge of tackling animal viruses at a North African conference. Professor Munir Iqbal, Dr Donald King and Dr Georgina Limon-Vega addressed an audience of vets and representatives from animal health…
Read more

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