Samuel Hardy is a PhD student working to characterise the inhibition of the innate apoptotic response by classical swine fever virus (CSFV). He began his studies at The Pirbright Institute in 2015 after graduating from the University of Reading with a degree in microbiology.
Classical swine fever is a haemorrhagic disease of pigs and wild boar which is of great economic importance. The virus is endemic in large parts of Africa, Asia and South America. Npro, a viral protein encoded by CSFV, inhibits virus-induced cell death in some cells types, contributing towards the disease’s immunopathology.
Samuel will be employing a range of cellular, molecular and biophysical techniques in order to determine the nature of and mechanisms behind this inhibition. Work carried out during his project will contribute towards our understanding of the virus and inform the future development of novel vaccines and anti-virals.
Samuel is currently supervised by Dr Julian Seago and Dr Liz Reid at The Pirbright Institute and Professor Steve Goodbourn at St George’s, University of London.