Prof Pippa Hawes

Group Leader

Dr Pippa Hawes is an experienced, qualified microscopist with an established track-record in imaging virally infected animal cells and tissue. Pippa has specific expertise in confocal and electron microscopy and its application to the study of virus-host interactions. With over 14 years’ experience operating, running and installing instruments in a high containment facility, Pippa has become an expert in this niche but expanding area of imaging.

She is regularly invited to lecture at residential courses and events in UK and further afield. Well known within the microscopy community she is a member of the Council of the Royal Microscopical Society and an active supporter of ImagingUK. Pippa believes training and passing on knowledge to inspire future generations of scientists, particularly microscopists, is an important role for current researchers.

Recently, Pippa secured funding from the Biotechnology and Biological Sciences Research Council to expand the microscopy capabilities of The Pirbright Institute to include superresolution light microscopy and advanced transmission electron microscopy. Consequently two new confocal laser scanning microscopes (Leica SP8 and Leica SP8 STED), a new 200kV TEM (JEOL 2100F) with in-column gaseous decontamination system, and a 120kV TEM (FEI T12) have recently been installed in the bespoke Bioimaging Suite within the National Virology Centre: Plowright building at Pirbright.

News
Publications

Pirbright discovers respiratory virus steals proteins to halt antiviral response

Pirbright scientists contribute to new coronavirus book

Pirbright scientists show how infectious bursal disease viruses may swap genetic material during infection

Pirbright study uncovers replication sites of emerging pig disease

Pirbright enters bioimaging collaboration with Diamond Light Source

Sanz-Bernardo B, Haga I R, Wijesiriwardana N, Basu S, Larner W, Diaz A V, Langlands Z, Denison E, Stoner J, White M, Sanders C, Hawes P C, Wilson A J, Atkinson J, Batten C, Alphey L, Darpel K E, Gubbins S, Beard P M (2020)

Quantifying and modelling the acquisition and retention of lumpy skin disease virus by haematophagus insects reveals clinically but not subclinically-affected cattle are promoters of viral transmission and key targets for control of disease outbreaks

bioRxiv preprint , 2020.06.18.154252

Publisher’s version: https://doi.org/10.1101/2020.06.18.154252

Campbell E A, Reddy V R A P, Gray A G, Wells J, Simpson J, Skinner M A, Hawes P C, Broadbent A J (2020)

Discrete virus factories form in the cytoplasm of cells co-infected with two replication competent tagged reporter birnaviruses, that subsequently coalesce over time

Journal of Virology Early view

Publisher’s version: https://doi.org/10.1128/JVI.02107-19

Jobe F, Simpson J, Hawes P, Guzman E, Bailey D (2020)

Respiratory syncytial virus sequesters NF-κB subunit p65 to cytoplasmic inclusion bodies to inhibit innate immune signalling

Journal of Virology early view

Publisher’s version: https://doi.org/10.1128/JVI.01380-20

Jobe F, Simpson J, Hawes P, Guzman E, Bailey D (2020)

Respiratory syncytial virus sequesters NF-κB subunit p65 to cytoplasmic inclusion bodies to inhibit innate immune signalling

bioRxiv , 944363

Publisher’s version: https://doi.org/10.1101/2020.02.11.944363

Sanz-Bernardo B, Haga I R, Wijesiriwardana N, Hawes P C, Simpson J, Morrison L R, MacIntyre N, Brocchi E, Atkinson J, Haegeman A, De Clercq K, Darpel K E, Beard P M (2020)

Lumpy skin disease is characterized by severe multifocal dermatitis with necrotizing fibrinoid vasculitis following experimental infection

Veterinary Pathology 57 (3) , 388-396

Publisher’s version: https://doi.org/10.1177/0300985820913268

Doyle N, Hawes P C, Simpson J, Adams L H, Maier H J (2019)

The porcine deltacoronavirus replication organelle comprises double-membrane vesicles and zippered endoplasmic reticulum with double-membrane spherules

Viruses 11 (11)

Publisher’s version: https://doi.org/10.3390/v11111030

Research programme

Bioimaging

Groups

Bioimaging

Prof Pippa Hawes

Pirbright discovers respiratory virus steals proteins to halt antiviral response

Pirbright scientists contribute to new coronavirus book

Pirbright scientists show how infectious bursal disease viruses may swap genetic material during infection

Pirbright study uncovers replication sites of emerging pig disease

Pirbright enters bioimaging collaboration with Diamond Light Source

Quantifying and modelling the acquisition and retention of lumpy skin disease virus by haematophagus insects reveals clinically but not subclinically-affected cattle are promoters of viral transmission and key targets for control of disease outbreaks

Discrete virus factories form in the cytoplasm of cells co-infected with two replication competent tagged reporter birnaviruses, that subsequently coalesce over time

Respiratory syncytial virus sequesters NF-κB subunit p65 to cytoplasmic inclusion bodies to inhibit innate immune signalling

Respiratory syncytial virus sequesters NF-κB subunit p65 to cytoplasmic inclusion bodies to inhibit innate immune signalling

Lumpy skin disease is characterized by severe multifocal dermatitis with necrotizing fibrinoid vasculitis following experimental infection

The porcine deltacoronavirus replication organelle comprises double-membrane vesicles and zippered endoplasmic reticulum with double-membrane spherules

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Prof Pippa Hawes

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