Dr Sushant Bhat

Real name:

Postdoctoral Scientist

High containment work (ACDP 3 and 4), Molecular Virology, Vaccines, Vaccinology, Veterinary Medicine, Viral Diseases, Virology

Sushant Bhat was born in Srinagar, Jammu & Kashmir, India. Starting his professional career as a veterinary graduate, he completed bachelor’s degree in veterinary science and animal husbandry (B.V.Sc & A.H) in the year 2009 from GADVASU, Ludhiana, India. He started his research career in 2009 working on development and characterization of monoclonal antibodies against nucleoprotein of (HPAI) H5N1 avian influenza virus. During his doctoral research work, carried out at ICAR-NIHSAD (an OIE reference lab for Avian Influenza), Bhopal, India, he worked on the development of a reverse genetics-based DIVA marker vaccine against HPAI H5N1 viruses as a control strategy for HPAI avian influenza infections in chickens. He obtained his PhD degree from Indian Veterinary Research Institute, Bareilly, India in the year 2015. Sushant gained experience working in ICAR-NIHSAD’s Biosafety Level 3 (BSL3) lab and Animal Biocontainment facility (BSL3+). Later, he joined The Pirbright Institute in the year 2016 to work in ACDP3/SAPO4 containment labs as an Influenza Molecular Virologist. He works in Prof. Munir Iqbal’s Avian Influenza group and is mainly focused on studying Molecular Virology and Vaccinology. His work areas include-

Studying influenza virus reassortment in poultry birds.
Development of next-generation vaccine technology inducing rapid and strong immunity through targeted delivery of antigens to chicken immune cells.

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Researchers at Pirbright investigate the emergence of new bird flu viruses with the potential to infect people

Early animal studies by Pirbright and Oxford yield promising results for new potential COVID-19 vaccine

Pirbright study shows how SARS-CoV-2 could have adapted from bats to humans and which other animals it could infect

Pirbright scientists reveal more clues on how bird flu viruses evade vaccine immunity

Pirbright shows bird flu mutations could increase threat to poultry, but reduce potential to infect humans

James, J, Bhat, S, Walsh, SK, Karunarathna, TK, Sadeyen, J-R, Chang, P, Sealy, JE, Mahmood, S, Mollett, BC, Slomka, MJ, Brookes, SM and Iqbal, M (2022)

The origin of internal genes contributes to the replication and transmission fitness of H7N9 avian influenza virus

Journal of Virology

Publisher’s version: https://doi.org/10.1128/jvi.01290-22

Panickan, S, Bhatia, S, Bhat, S, Bhandari, N, Pateriya, AK, Kalaiyarasu, S, Sood, R and Tripathi, M (2022)

Reverse genetics based H5N2 vaccine provides clinical protection against H5N1, H5N8 and H9N2 avian influenza infection in chickens

Vaccine 40 (48) , 6998-7008

Publisher’s version: https://doi.org/10.1016/j.vaccine.2022.10.018

Bhat S, James J, Sadeyen J-R, Mahmood S, Everest H J, Chang P, Walsh S K, Byrne A M P, Mollett B, Lean F, Sealy J E, Shelton H, Slomka M J, Brookes S M, Iqbal M (2022)

Coinfection of chickens with H9N2 and H7N9 avian influenza viruses leads to emergence of reassortant H9N9 virus with increased fitness for poultry and a zoonotic potential

Journal of Virology 96 (5) , e0185621

Publisher’s version: https://doi.org/10.1128/jvi.01856-21

Sood R, Kumar N, Gokhe S S, Pateriya A K, Bhat S, Bhatia S, Panickan S, Mishra A, Murugkar H V, Dixit R, Shrivastava D, Singh P, Tripathi M, Singh V P (2021)

Identification and molecular characterization of H9N2 viruses carrying multiple mammalian adaptation markers in resident birds in central-western wetlands in India

Infection, Genetics and Evolution 94 , 105005

Publisher’s version: https://doi.org/10.1016/j.meegid.2021.105005

Conceicao C, Thakur N, Human S, Kelly J T, Logan L, Bialy D, Bhat S, Stevenson-Leggett P, Zagrajek A K, Hollinghurst P, Varga M, Tsirigoti C, Hammond J A, Maier H J, Bickerton E, Shelton H, Dietrich I, Graham S C, Bailey D (2020)

The SARS-CoV-2 spike protein has a broad tropism for mammalian ACE2 proteins

PLOS Biology 18 (12) , e3001016

Publisher’s version: https://doi.org/10.1371/journal.pbio.3001016

Sealy J E, Peacock T P, Sadeyen J-R, Chang P, Everest H J, Bhat S, Iqbal M (2020)

Adsorptive mutation and N-linked glycosylation modulate influenza virus antigenicity and fitness

Emerging Microbes and Infections 9 (1) , 2622-2631

Publisher’s version: https://doi.org/10.1080/22221751.2020.1850180

Groups

Avian Influenza Virus

Dr Sushant Bhat

Researchers at Pirbright investigate the emergence of new bird flu viruses with the potential to infect people

Early animal studies by Pirbright and Oxford yield promising results for new potential COVID-19 vaccine

Pirbright study shows how SARS-CoV-2 could have adapted from bats to humans and which other animals it could infect

Pirbright scientists reveal more clues on how bird flu viruses evade vaccine immunity

Pirbright shows bird flu mutations could increase threat to poultry, but reduce potential to infect humans

The origin of internal genes contributes to the replication and transmission fitness of H7N9 avian influenza virus

Reverse genetics based H5N2 vaccine provides clinical protection against H5N1, H5N8 and H9N2 avian influenza infection in chickens

Coinfection of chickens with H9N2 and H7N9 avian influenza viruses leads to emergence of reassortant H9N9 virus with increased fitness for poultry and a zoonotic potential

Identification and molecular characterization of H9N2 viruses carrying multiple mammalian adaptation markers in resident birds in central-western wetlands in India

The SARS-CoV-2 spike protein has a broad tropism for mammalian ACE2 proteins

Adsorptive mutation and N-linked glycosylation modulate influenza virus antigenicity and fitness

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