Dr Richard Borne
Richard Borne graduated from Aston University with a 2:1 in Infection and Immunity in 2013 and then studied for his MRes in Molecular Microbiology at the University of Exeter. He is currently a PhD student in the Immunogenetics Group at The Pirbright Institute, registered with the University of Glasgow, studying cattle natural killer (NK) cell receptors. NK receptor repertoires evolve independently in different mammalian lineages and as a result the NK receptor repertoire of cattle is unique. The receptor repertoire also has a great deal of diversity, which leads to varied immune responses both at the individual cell level and between different animals.
During his PhD project Richard will utilise a combination of molecular and next generation sequencing techniques, such as transcriptomics, ribosome profiling and proteomics which will allow the identification and quantification of the genes that are expressed during the NK response. Comparisons of NK cells isolated from different immunological compartments within cattle will aid the understanding of how NK cells acquire their diverse receptor repertoires. This knowledge will then be used in the development of viral infection models which will allow the effect of receptor diversity on the immune response to be seen.