Dr John Schwartz

Real name:

Senior Postdoctoral Scientist

Bioinformatics, Genetics, Genomics, Immunology

John Schwartz’s research focuses on characterising the genomic diversity of immune genes. He obtained his PhD in 2013 from the University of Minnesota where he studied the porcine B-cell repertoire.

His current work involves characterising the organisation, evolution, and the diversity of genes which encode immune cell receptors in mammalian species. These include genes of the major histocompatibility complex (MHC), leukocyte receptor complex (LRC), natural killer complex (NKC), the B-cell and T-cell receptor loci, and Fc receptors. He is interested in the application of this knowledge in identifying the genetic bases of disease resistance, and ultimately to inform livestock breeding programmes for the development of disease-resistant animals.

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News
Publications

Pirbright generates first pig flu antibodies that could improve human treatments and guide flu vaccine selection

Pirbright scientists uncover goat immune genes involved in natural resistance

Pig immunology comes of age: killer T cell responses to influenza

Position and function of goat antibody genes identified at Pirbright

Technique used to generate new goat genome assembly sets the standard for future projects.

Schwartz J, Lefranc M-P, Murtaugh M (2012)

Organization, complexity and allelic diversity of the porcine (Sus scrofa domestica) immunoglobulin lambda locus

Immunogenetics 64 (5) , 399-407

Publisher’s version: http://dx.doi.org/10.1007/s00251-011-0594-9

Schwartz J C, Lefranc M-P, Murtaugh M P (2012)

Evolution of the porcine (Sus scrofa domestica) immunoglobulin kappa locus through germline gene conversion

Immunogenetics 64 (4) , 303-311

Publisher’s version: http://dx.doi.org/10.1007/s00251-011-0589-6

Groenen M A M, Archibald A L, Uenishi H, Tuggle C K, Takeuchi Y, Rothschild M F, Rogel-Gaillard C, Park C, Milan D, Megens H-J, Li S, Larkin D M, Kim H, Frantz L A F, Caccamo M, Ahn H, Aken B L, Anselmo A, Anthon C, Auvil L, Badaoui B, Beattie C W, Bendixen C, Berman D, Blecha F, Blomberg J, Bolund L, Bosse M, Botti S, Bujie Z, Bystrom M, Capitanu B, Carvalho-Silva D, Chardon P, Chen C, Cheng R, Choi S-H, Chow W, Clark R C, Clee C, Crooijmans R P M A, Dawson H D, Dehais P, De Sapio F, Dibbits B, Drou N, Du Z-Q, Eversole K, Fadista J, Fairley S, Faraut T, Faulkner G J, Fowler K E, Fredholm M, Fritz E, Gilbert J G R, Giuffra E, Gorodkin J, Griffin D K, Harrow J L, Hayward A, Howe K, Hu Z-L, Humphray S J, Hunt T, Hornshoj H, Jeon J-T, Jern P, Jones M, Jurka J, Kanamori H, Kapetanovic R, Kim J, Kim J-H, Kim K-W, Kim T-H, Larson G, Lee K, Lee K-T, Leggett R, Lewin H A, Li Y, Liu W, Loveland J E, Lu Y, Lunney J K, Ma J, Madsen O, Mann K, Matthews L, McLaren S, Morozumi T, Murtaugh M P, Narayan J, Truong Nguyen D, Ni P, Oh S-J, Onteru S, Panitz F, Park E-W, Park H-S, Pascal G, Paudel Y, Perez-Enciso M, Ramirez-Gonzalez R, Reecy J M, Rodriguez-Zas S, Rohrer G A, Rund L, Sang Y, Schachtschneider K, Schraiber J G, Schwartz J, Scobie L, Scott C, Searle S, Servin B, Southey B R, Sperber G, Stadler P, Sweedler J V, Tafer H, Thomsen B, Wali R, Wang J, Wang J, White S, Xu X, Yerle M, Zhang G, Zhang J, Zhang J, Zhao S, Rogers J, Churcher C, Schook L B (2012)

Analyses of pig genomes provide insight into porcine demography and evolution

Nature 491 (7424) , 393-398

Publisher’s version: http://dx.doi.org/10.1038/nature11622

Dawson H D, Loveland J E, Pascal G, Gilbert J G, Uenishi H, Mann K M, Sang Y, Zhang J, Carvalho-Silva D, Hunt T, Hardy M, Hu Z, Zhao S H, Anselmo A, Shinkai H, Chen C, Badaoui B, Berman D, Amid C, Kay M, Lloyd D, Snow C, Morozumi T, Cheng R P, Bystrom M, Kapetanovic R, Schwartz J C, Kataria R, Astley M, Fritz E, Steward C, Thomas M, Wilming L, Toki D, Archibald A L, Bed'Hom B, Beraldi D, Huang T H, Ait-Ali T, Blecha F, Botti S, Freeman T C, Giuffra E, Hume D A, Lunney J K, Murtaugh M P, Reecy J M, Harrow J L, Rogel-Gaillard C, Tuggle C K (2013)