Dr Andrew Broadbent

Real name:

Honorary Fellow

Immunology, Vaccinology, Virology

Dr Andrew Broadbent led the birnaviruses group at Pirbright that conducted research into the pathogenesis and control of avian immunosuppressive viruses that can exacerbate the spread of zoonotic diseases. He holds a degree in Veterinary Medicine from the University of Cambridge, a Masters degree from the London School of Hygiene and Tropical Medicine (LSHTM), and a PhD in Microbiology and Immunology from Imperial College London. Prior to joining Pirbright, Andrew was a Postdoctoral Fellow at the National Institutes of Health (NIH) in the US.

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Publications

IBDV protein that dampens poultry immune response could inform vaccine development

Pirbright scientists show how infectious bursal disease viruses may swap genetic material during infection

Science Spotlight: Dr Andrew Broadbent

Pirbright innovation recognised at the BBSRC Innovator of the Year Awards

Pirbright scientists produce lab technique which reduces need for experimental chickens

Dulwich K L, Asfor A, Gray A, Giotis E S, Skinner M A, Broadbent A J (2020)

The stronger downregulation of in vitro and in vivo innate antiviral responses by a very virulent strain of infectious bursal disease virus (IBDV), compared to a classical strain, is mediated, in part, by the VP4 protein

Frontiers in Cellular and Infection Microbiology 10 , 315

Publisher’s version: https://doi.org/10.3389/fcimb.2020.00315

Campbell E A, Reddy V R A P, Gray A G, Wells J, Simpson J, Skinner M A, Hawes P C, Broadbent A J (2020)

Discrete virus factories form in the cytoplasm of cells co-infected with two replication competent tagged reporter birnaviruses, that subsequently coalesce over time

Journal of Virology 94 (13) , e02107-19

Publisher’s version: https://doi.org/10.1128/JVI.02107-19

Dulwich K L, Asfor A S, Gray A G, Venugopal N, Broadbent A J (2018)

An ex vivo chicken primary bursal-cell culture model to study infectious bursal disease virus pathogenesis

Journal of Visualized Experiments 140 , e58489

Publisher’s version: https://doi.org/10.3791/58489

Sadigh Y, Powers C, Spiro S, Pedrera M, Broadbent A, Nair V (2018)

Gallid herpesvirus 3 SB-1 strain as a recombinant viral vector for poultry vaccination

npj Vaccines 3 (1) , 21

Publisher’s version: https://dx.doi.org/10.1038/s41541-018-0056-6

Dulwich K L, Giotis E S, Gray A, Nair V, Skinner M A, Broadbent A J (2017)

Differential gene expression in chicken primary B cells infected ex vivo with attenuated and very virulent strains of infectious bursal disease virus (IBDV)

Journal of General Virology 98 (12) , 2918-2930

Publisher’s version: http://dx.doi.org/10.1099/jgv.0.000979

Soubies S M, Courtillon C, Abed M, Amelot M, Keita A, Broadbent A, Hartle S, Kaspers B, Eterradossi N (2017)

Propagation and titration of infectious bursal disease virus, including non-cell-culture-adapted strains, using ex vivo stimulated chicken bursal cells

Avian Pathology 47 (2) , 179-188

Publisher’s version: http://dx.doi.org/10.1080/03079457.2017.1393044

Dr Andrew Broadbent

IBDV protein that dampens poultry immune response could inform vaccine development

Pirbright scientists show how infectious bursal disease viruses may swap genetic material during infection

Science Spotlight: Dr Andrew Broadbent

Pirbright innovation recognised at the BBSRC Innovator of the Year Awards

Pirbright scientists produce lab technique which reduces need for experimental chickens

The stronger downregulation of in vitro and in vivo innate antiviral responses by a very virulent strain of infectious bursal disease virus (IBDV), compared to a classical strain, is mediated, in part, by the VP4 protein

Discrete virus factories form in the cytoplasm of cells co-infected with two replication competent tagged reporter birnaviruses, that subsequently coalesce over time

An ex vivo chicken primary bursal-cell culture model to study infectious bursal disease virus pathogenesis

Gallid herpesvirus 3 SB-1 strain as a recombinant viral vector for poultry vaccination

Differential gene expression in chicken primary B cells infected ex vivo with attenuated and very virulent strains of infectious bursal disease virus (IBDV)

Propagation and titration of infectious bursal disease virus, including non-cell-culture-adapted strains, using ex vivo stimulated chicken bursal cells

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Dr Andrew Broadbent

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