Scientists at The Pirbright Institute have shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for coronavirus disease (COVID-19), is able to enter cells using the receptors of multiple mammalian species. The broad host range of SARS-CoV-2 confirms the potential risk of infection to a wide range of companion animals, livestock and wildlife.
Scientists from The Pirbright Institute are a step closer to developing a vital vaccine for African swine fever (ASF), a pig disease that the World Organisation for Animal Health (OIE) has warned could kill a quarter of the world’s pigs, partly due to the absence of a commercially available vaccine. Their study, published in Vaccines showed that 100 percent of pigs immunised with the new vaccine were protected from a lethal dose of ASF virus (ASFV).
Scientists in the Non-Vesicular Reference Laboratory (NVRL) at The Pirbright Institute have confirmed an outbreak of African horse sickness (AHS) in Thailand. AHS is the most lethal viral disease of horses known and the rapid diagnostic services provided by Pirbright has enabled authorities to respond quickly to the outbreak, the first that south-east Asia has ever experienced.
Scientists from The Pirbright Institute have worked with UCL to map the expression of genes across the entire African swine fever virus (ASFV) genome, which has helped to establish their order of activation as well as uncovering new genes. The research could provide vital information for those developing vaccines and antiviral drugs to prevent the deadly pig disease caused by this virus.
New strategic bioimaging collaboration announced between The Pirbright Institute and Diamond Light Source
A new five-year collaboration agreement is now in place between The Pirbright Institute and Diamond Light Source, which aims to enable scientists to study viral diseases in greater detail.
Bill & Melinda Gates Foundation funds development of Pirbright’s Livestock Antibody Hub supporting animal and human health
Researchers from The Pirbright Institute have been awarded US $5.5 million by the Bill & Melinda Gates Foundation to establish a Livestock Antibody Hub aimed at improving animal and human health globally. The ambitious programme of work will see extensive collaboration between multiple UK research organisations in order to utilise research outcomes in livestock disease and immunology to support human health as part of the ‘One Health’ agenda.
Collaborative research has shown that a new vaccine, ChAdOx1 RVF, is effective at protecting pregnant sheep and goats from Rift Valley fever (RVF), a debilitating disease that can also be transmitted to humans. Scientists from The Pirbright Institute worked with The Jenner Institute at the University of Oxford, Wageningen Bioveterinary Research in the Netherlands, BioVacc Consulting Ltd and the KEMRI-Wellcome Trust Research Programme in Kenya on this project.
Scientists from The Pirbright Institute and The Roslin Institute have launched The Immunological Toolbox, a website that provides a platform for veterinary researchers to find resources and collaborate. The Toolbox aims to remove barriers to veterinary vaccine development by providing a central database of reagents and aiding information exchange.
The Pirbright Institute has entered into a worldwide exclusive partnership with ECO Animal Health Ltd (ECO), a wholly owned subsidiary of ECO Animal Health Group plc, on two new projects to combat significant diseases of poultry.
The Pirbright Institute and its research partners have granted MSD Animal Health an exclusive commercial licence for a new, effective and affordable vaccine to protect livestock against several serotypes of foot-and-mouth disease virus (FMDV). The new vaccine is more stable than current foot-and-mouth disease (FMD) vaccines and is less reliant on a cold-chain during vaccine distribution – characteristics that give the vaccine greater potential for helping to relieve the burden placed on regions where the disease is endemic in large parts of Africa, the Middle East and Asia.