Dr Muhammad Munir
Whilst studying Veterinary Medicine, Muhammad Munir was offered an opportunity to work on viral immunology at the Swedish University of Agricultural Sciences, Uppsala, Sweden. During PhD, Muhammad has studied molecular mechanisms of interferon (IFN) antagonism by non-structural proteins of avian and human viruses including influenza, borna, and Newcastle disease viruses. Since 2013, Dr Munir is working as Fellow at The Pirbright Institute, UK and is heading a group on Infection and Innate Immunity.
The primary research interests of Dr Munir are to understand the innate immune responses in different avian hosts that range from sensing of viruses to terminal IFN effectors mediated by myriad of interferon-stimulated and virus-regulated genes. Employing large-scale, genome-wide and high-throughput screening platforms, his group is deciphering differential host responses to diverse avian pathogens, and understanding the bases for genetic resistance/susceptibility of different avian species. Additionally, applying genome-wide transcriptomics and proteomics approaches, the group of Dr Munir is trying to understand molecular determinants of viral pathogenesis (infection) and the ways avian viruses (e.g. Newcastle disease virus and influenza viruses) have adapted to avoid innate immune responses in avian hosts. Dr Munir has authored more than 80 peer-reviewed research and review articles, 8 chapters on viruses and immunity, and has written and edited 5 books with Springer, Germany and CABI, UK publishers.
Ongoing Projects (as PI)
- Bilateral BBSRC-FAPESP Research Grant (2015-2019): Dissecting Essential Roles of Chicken Interferon Stimulated Genes in the Pathobiology of Poultry Viruses.
- Royal Society (2015-2017): Construction of an interferon stimulatory gene mini-library for chiropteran species and assessment of the expression dynamics of bat interferon stimulated genes (baISGs)
- Newtons Fund by British Council (2015-2018): Preparedness for novel virus emergence from wild birds and bats: metagenomics-driven viromes and understanding innate immunity.
- Royal Society (2016-2017): Triple-Reporter Cell Lines for Screening of Antiviral and Viral Immune Modulator
- BBSRC-Pirbright Institute (2014-2018): Evasion of host innate immunity by Newcastle Disease Virus (NDV) and its pathogenic consequences.
- BBSRC (2014-2017): Brazil Partnering Award: Population genetic diversity of wild birds and its influence on virus evolution and biology in Brazil.
- Newton Funds-British Council PhD Studentship (2015-2019): Immunological Bases of NDV-Induced Oncolysis.
- BBSRC-BBS/E/I/00001852. Genetic diversity in immune response
Current Project (Co-PI):
- BBSRC (2016-2019): Dissecting the role of TGF-beta+ regulatory CD4+ T cells in pathogenesis of Marek's disease in chickens
- British Council (2015, PI): Construction of a genotype-matched Newcastle disease virus vaccine
- ResearchersLinks (UK-Malaysia, 2016, PI): Emerging and Next Generation Vaccine Strategies Against Veterinary Viruses
- Science and Technology Development Fund (2016, PI): Continuous Evolution of Newcastle Disease Virus under Mixed Infection with Other Respiratory Viruses
- Swedish Research Council (2014-2017, Co-PI): Factors determining susceptibility of peste des petits ruminants virus infections in domestic and wild small ruminants
- Diwakar Santhakumar
- Ana Cláudia Franco
- Archana Jadave
- Manoja Rasamanikkam (Shared Studentship with Prof Goodbourn)
- Guilherme Pereira Scagion
- Mohammed Abdel Mohsen Rohaim
- Rania El Naggar
- Carla Meneguin Barbosa
- Santhakumar D, Rubbenstroth D, Martinez-Sobrido L, Munir M (2017) Avian interferons and their antiviral effectors Frontiers in Immunology 8, 49. Publisher’s version: http://journal.frontiersin.org/article/10.3389/fimmu.2017.00049
- Santhakumar D, Iqbal M, Nair V, Munir M (2017) Chicken IFN Kappa: a novel cytokine with antiviral activities Scientific Reports 7 (1), 2719 Publisher’s version: http://dx.doi.org/10.1038/s41598-017-02951-2
- Goraya M, Wang S, Munir M, Chen J-L (2015) Induction of innate immunity and its perturbation by influenza viruses. Protein and Cell 6 (10), 712-721. Publisher’s version: http://dx.doi.org/10.1007/s13238-015-0191-z
- Z.U. Rehman, C. Meng, S. Umar, K.M. Mahrose, C. Ding And M. Munir (2017). Mast cells and innate immunity: master troupes of the avian immune system. World's Poultry Science Journal (ahead of print). Publisher’s version: DOI: https://doi.org/10.1017/S0043933917000526.
- Li L-F, Yu J, Li Y, Wang J, Li S, Zhang L, Xia S-L, Yang Q, Wang X, Yu S, Luo Y, Sun Y, Zhu Y, Munir M, Qiu H-J (2016). Guanylate-binding protein 1, an interferon-induced GTPase, exerts an antiviral activity against classical swine fever virus depending on its GTPase activity. Journal of Virology 90 (9), 4412-4426. Publisher’s version: http://dx.doi.org/10.1128/jvi.02718-15
- Wang J, Chen S, Liao Y, Zhang E, Feng S, Yu S, Li L-F, He W-R, Li Y, Luo Y, Sun Y, Zhou M, Wang X, Munir M, Li S, Qiu H-J (2016). Mitogen-activated protein kinase kinase 2 (MEK2), a novel E2-interacting protein, promotes the growth of classical swine fever virus via attenuation of the JAK-STAT signaling pathway. Journal of Virology 90 (22), 10271-10283. Publisher’s version: http://dx.doi.org/10.1128/jvi.01407-16
- Munir M, Berg M (2013). The multiple faces of proteinkinase R in antiviral defense. Virulence 4 (1), 85-89. Publisher’s version: http://dx.doi.org/10.4161/viru.23134
- Munir M (2010) TRIM proteins: another class of viral victims Science Signaling 3 (118), jc2 Publisher’s version: http://dx.doi.org/10.1126/scisignal.3118jc2
- Munir M, Zohari S, Iqbal M, Abbas M, Perez D R, Berg M (2013) The non-structural (NS) gene segment of H9N2 influenza virus isolated from backyard poultry in Pakistan reveals strong genetic and functional similarities to the NS gene of highly pathogenic H5N1. Virulence 4 (7), 612-623. Publisher’s version: http://dx.doi.org/10.4161/viru.26055
- Shabbir M Z, Akhtar S, Tang Y, Yaqub T, Ahmad A, Mustafa G, Alam M A, Santhakumar D, Nair V, Munir M (2016). Infectivity of wild bird origin avian paramyxovirus serotype 1 and vaccine effectiveness in chickens. Journal of General Virology 97 (10), 3161-3173. Publisher’s version: http://dx.doi.org/10.1099/jgv.0.000618
- Satharasinghe D A, Murulitharan K, Tan S W, Yeap S K, Munir M, Ideris A, Omar A R (2016). Detection of inter-lineage natural recombination in avian paramyxovirus serotype 1 using simplified deep sequencing platform. Frontiers in Microbiology 7, 1907. Publisher’s version: http://dx.doi.org/10.3389/fmicb.2016.01907
- Orabi A, Hussein A, Saleh A A, El-Magd M A, Munir M (2017) Evolutionary insights into the fusion protein of Newcastle disease virus isolated from vaccinated chickens in 2016 in Egypt
Archives of Virology early online, Publisher’s version: http://dx.doi.org/10.1007/s00705-017-3483-1
- Rohaim M A, El Naggar R F, Helal A M, Hussein H A, Munir M (2017). Reverse spillover of avian viral vaccine strains from domesticated poultry to wild birds Vaccine 35 (28), 3523-3527 Publisher’s version: http://dx.doi.org/10.1016/j.vaccine.2017.05.033
- Muhammad Munir (Editor), Mononegaviruses of Veterinary Importance. Volume I: Pathobiology and Molecular Diagnosis. ISBN: 9781780641799Explore the book: http://dx.doi.org/10.1079/9781780641799.0000
- Muhammad Munir (Editor), Mononegaviruses of Veterinary Importance, Volume II: Molecular Epidemiology and Control. ISBN: 9781780644172 Explore the book: http://www.cabi.org/bookshop/book/9781780644172
- Muhammad Munir (author), Siamak Zohari, Mikael Berg. Molecular Biology and Pathogenesis of Peste des Petits Ruminants Virus. ISBN: 978-3-642-31451-3 Explore the book http://www.springer.com/us/book/9783642314506
- Muhammad Munir (Editor), Peste des Petits Ruminants Virus. ISBN 978-3-662-45165-6 Explore the book http://www.springer.com/gb/book/9783662451649#aboutBook
- Helena Lage Ferreira,Taiana Pereira da Costa, Cintia Hiromi Okino Keeler, Shamus Patrick; Muhammad Munir. Main challenges in poultry farming. Avian influenza. Explore the book: http://store.grupoasis.com/en/poultry/561-main-challenges-in-poultry-far...