The successful applicant will be a key member of the birnavirus group and will report directly to the head of the group. The position is part of a two-year funded NC3Rs project to develop a chicken primary B cell culture model to investigate the interaction of immunosuppressive viruses with avian B cells.
Immunosuppression is a major problem in the poultry industry, with many cases being the result of infection with lymphotropic viruses. Recently, it became possible to maintain chicken primary B cells in the laboratory for long enough to study how viruses interact with them. The successful candidate will build on this work and further develop the model to study how the chicken primary B cells respond to infection with the following viruses: infectious bursal disease virus (IBDV), avian leucosis virus (ALV) and reticuloendotheliosis virus (REV). These viruses are of major economic importance to the poultry industry and, by characterizing host-virus interactions in detail, the work can help lead to better control strategies. Moreover, the findings could be translated to other B-cell tropic viruses of importance to animals and people.
The successful candidate will be involved with in vivo, ex vivo and in vitro studies, and will be using techniques involved in cell-culture and classical molecular biology, as well as cutting-edge RNA-Sequencing (RNA-Seq) technology.
You will perform key research, administrative and management duties and the work will involve travel to meet with collaborators at Imperial College London